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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

IWR-1-endo ≥98%

Supplier: Van Der Voort Lucht en Milieu Amste

AG-CR1-3581-M005 AG-CR1-3581-M025
102988-638EA 124.62 USD InStock
102988-638 102988-640
IWR-1-endo ≥98%
IWR-1-endo
Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of beta-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3beta. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3beta. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay).


Formula: C₂₅H₁₉N₃O₃
MW: 409.4 g/mol
Storage Temperature: Freezer
 MDL Number: MFCD18086875
CAS Number: 1127442-82-3
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Specification Test Results
Purity 98%
Appearance/Color White to off-white solid.
Solubility Soluble in DMSO or DMF.

 

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