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2,5-Dimethyl-celecoxib 99

Supplier: Van Der Voort Lucht en Milieu Amste
Danger

AG-CR1-3599-M005 AG-CR1-3599-M025
102988-726EA 83.08 USD InStock
102988-726 102988-728
2,5-Dimethyl-celecoxib 99
2,5-Dimethyl-celecoxib
Close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib, that lacks COX-2 inhibitory function. Anti-proliferative, anti-tumorigenic and anti-angiogenic. Potent apoptosis inducer in many cancer cell lines. Down-regulates the expression of survivin, cyclins, MMPs and inhibits cyclin-dependent kinase activity. Modulates PDK-1, AKT, GSK3beta, p70 S6K, PKA and MAPKAP-K1alpha. Reduces phosphorylation of ERK1/2 but not AKT T-308 or AKT S-473. Increases intracellular free calcium levels and potently triggers the endoplasmatic reticulum stress response (ESR), activating ER stress-associated proteins GRP78/BiP, CHOP/GADD153 and caspase-4.


Formula: C₁₈H₁₆F₃N₃O₂S
MW: 395.4 g/mol
Storage Temperature: Freezer
 MDL Number: MFCD19443858
CAS Number: 457639-26-8
UN: 2811
ADR: 6.1 III
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Specification Test Results
Purity 99% (HPLC)
Appearance/Color White solid.
Solubility Soluble in DMSO, methanol or dichloromethane.

 

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