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MCC950 sodium salt ≥98%

Supplier: Van Der Voort Lucht en Milieu Amste
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AG-CR1-3615-M001 AG-CR1-3615-M005 AG-CR1-3615-M010
102988-774EA 48.46 USD InStock
102988-774 102988-776 102988-778
MCC950 sodium salt ≥98%
MCC950 sodium salt
Potent, selective and orally available NLRP3 inflammasome inhibitor. Blocks the release of IL-1beta in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Prevents oligomerization of ASC in cells stimulated with LPS and nigericin. Active in vivo, blocking the production of IL-1beta and enhancing survival in mouse models of multiple sclerosis and cryopyrin-associated periodic syndrome (CAPS). Also active in ex vivo samples from individuals with Muckle-Wells syndrome. Potential therapeutic agent for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases.


Formula: C₂₀H₂₃N₂NaO₅S
MW: 426.5 g/mol
Storage Temperature: Freezer
 MDL Number: MFCD30478884
CAS Number: 256373-96-3
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Specification Test Results
Purity 98% (HPLC)
Appearance/Color Crystalline solid.
Solubility Soluble in water, DMSO, dimethyl formamide or ethanol.

 

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