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Tofacitinib ≥98%

Supplier: Van Der Voort Lucht en Milieu Amste

Danger

AG-CR1-3625-M005 AG-CR1-3625-M025

102988-814EA 83.08 USD

102988-814 102988-816

Tofacitinib ≥98%

Tofacitinib

Potent cell permeable JAK3 inhibitor (IC50 = 1nM). Shows also JAK-1 inhibitory activity. Immunosuppressive and anti-inflammatory agent. Inhibits signaling through heterodimeric receptors associated with JAK3, JAK1, or both of them, with functional selectivity over JAK2-paired receptors. Blocks downstream STAT signaling, resulting in potent inhibition of several cytokines, including interleukins 2, 4, 7, 9, 15 and 21, which are integral to lymphocyte activation, function and proliferation. Investigated for several autoimmune disorders including, rheumatoid arthritis and psoriasis. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro.

Formula: C₁₆H₂₀N₆O
MW: 312.4 g/mol
Storage Temperature: Freezer

MDL Number: MFCD11035919
CAS Number: 477600-75-2
UN: 2811
ADR: 6.1 III

Specification Test Results

Purity	98%
Appearance/Color	Off-white to pale yellow solid.
Solubility	Soluble in DMSO or ethanol.

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