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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

N-Dodecanoyl-L-homoserine lactone ≥98%

Supplier: Van Der Voort Lucht en Milieu Amste

CDX-D0335-M005 CDX-D0335-M050
102989-792EA 88.62 USD InStock
102989-792 102989-794
N-Dodecanoyl-L-homoserine lactone ≥98%
N-Dodecanoyl-L-homoserine lactone
N-Dodecanoyl-L-homoserine lactone (C12-HSL) is a small diffusible signalling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria. In addition to regulating bacterial functions, C12-HSL activates NF-kappaB in RAW 264.7 macrophages, increasing the expression of TNF-alpha, interleukin-1beta (IL-1beta) and IL-8, while other lactones do not. In addition, C12-HSL alters cell cycling and metabolism of human keratinocyte (HaCaT) cells. It is important to note that C12-HSL is distinct from N-3-oxo-dodecanoyl-L-homoserine lactone, which is produced at different times in biofilm development and has different cellular effects.


Formula: C₁₆H₂₉NO₃
MW: 283.4 g/mol
Storage Temperature: Refrigerator
 MDL Number: MFCD11976890
CAS Number: 137173-46-7
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Specification Test Results
Source/Host Synthetic.
Purity 98% (NMR)
Appearance/Color White powder.
Solubility Soluble in DMSO and dimethylformamide (approx. 30mg/ml).

 

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