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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

5-[(4-Propyloxyphenyl)methylene]-2,4-thiazolidinedione (SMI-16a) ≥95%

Supplier: Van Der Voort Lucht en Milieu Amste

CDX-P0110-M005 CDX-P0110-M010 CDX-P0110-M050
102990-834EA 131.54 USD InStock
102990-834 102990-836 102990-838
5-[(4-Propyloxyphenyl)methylene]-2,4-thiazolidinedione (SMI-16a) ≥95%
5-[(4-Propyloxyphenyl)methylene]-2,4-thiazolidinedione (SMI-16a)
Potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1alpha (68% inhibition of DYRK1alpha and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (18% inhibition at 5 µM). Reported to exhibit antitumor activity in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20| 50 mg/kg via daily i.p.).


Formula: C₁₃H₁₃NO₃S
MW: 263.31 g/mol
Storage Temperature: Freezer
 MDL Number: MFCD31382191
CAS Number: 587852-28-6
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Specification Test Results
Source/Host Synthetic
Purity 95% (HPLC)
Appearance/Color Yellow powder.
Solubility Soluble in DMSO.

 

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