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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

Akt-I-1 ≥95%

Supplier: Van Der Voort Lucht en Milieu Amste

SYN-1005-M001 SYN-1005-M005 SYN-1005-M010
102991-202EA 292.15 USD InStock
102991-202 102991-204 102991-294
Akt-I-1 ≥95%
Akt-I-1
The compound (Akt-I-1) inhibits only Akt1 (IC(50) 4.6 µM) and does not inhibit AKT2, or AKT3. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of AKT1 isoform, AKT-I-1 blocked the phosphorylation and activation of AKT1 by PDK1 (phosphoinositide-dependent kinase 1). The inhibitor was found to be cell-active and to block phosphorylation of Akt at Thr308 and Ser473, reduce the levels of active Akt in cells, block the phosphorylation of known Akt substrates and promote TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand)-induced apoptosis in LNCap prostate cancer cells.


Formula: C₂₂H₃₀N₆
MW: 378.5 g/mol
Storage Temperature: Freezer
 MDL Number: MFCD16038643
CAS Number: 473382-39-7
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Specification Test Results
Purity 95%
Appearance/Color Solid.
Solubility Soluble in DMSO.

 

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