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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

Akt-I-2-hydrochloride ≥95%

Supplier: Van Der Voort Lucht en Milieu Amste

SYN-1006-M001 SYN-1006-M005 SYN-1006-M010
102991-296EA 292.15 USD InStock
102991-296 102991-298 102991-300
Akt-I-2-hydrochloride ≥95%
Akt-I-2-hydrochloride
The compound (Akt-I-2) inhibited both Akt1 and Akt2 with IC(50) values of 2.7 and 21 µM respectively. It does not inhibit AKT3. The compound is a reversible inhibitor, and exhibits a linear mixed-type inhibition against ATP and peptide substrate. In addition to inhibiting kinase activity of AKT1 and AKT2 isoforms, AKT-I-1,2 blocked the phosphorylation and activation of AKT1 and AKT2 by PDK1 (phosphoinositide-dependent kinase 1). The inhibitor was found to be cell-active and to block phosphorylation of Akt at Thr308 and Ser473, reduce the levels of active Akt in cells, block the phosphorylation of known Akt substrates and promote TRAIL (tumour-necrosis-factor-related apoptosis-inducing ligand)-induced apoptosis in LNCap prostate cancer cells.


Formula: C₂₃H₂₁N₃·HCl
MW: 375.9 g/mol
Storage Temperature: Freezer
 CAS Number: 473382-50-2
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Specification Test Results
Purity 95%
Appearance/Color Solid.
Solubility Soluble in DMSO.

 

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