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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

CC-401 hydrochloride ≥95%

Supplier: Van Der Voort Lucht en Milieu Amste

SYN-1028-M001 SYN-1028-M005 SYN-1028-M010 SYN-1028-M050
102991-462EA 171.69 USD InStock
102991-462 102991-464 102991-466 102991-468
CC-401 hydrochloride ≥95%
CC-401 hydrochloride
CC-401 is a competitive inhibitor of the ATP binding site in the active, phosphorylated, form of JNK. This prevents JNK from phosphorylating its various target molecules, including the amino terminus of c-Jun. It is a potent inhibitor of all three forms of JNK (Ki of 25-50 nM), and has at least 40-fold selectivity for JNK compared with other related kinases, including: p38, ERK, IKK2, PKC, Lck, and ZAP70. CC-401 acts to inhibit JNK signaling by competitive binding to the adenosine triphosphate-binding site in the active, phosphorylated, form of JNK, resulting in inhibition of the phosphorylation of JNK targets, such as the amino-terminal activation domain of the transcription factor, c-Jun. In cell-based assays, 1-5 muM CC-401 provides specific JNK inhibition.


Formula: C₂₂H₂₄N₆O·HCl
Storage Temperature: Freezer
 MDL Number: MFCD21364765
CAS Number: 1438391-30-0
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Specification Test Results
Purity 95%
Appearance/Color Solid.
Solubility Soluble in DMSO.

 

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