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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

AMG-51 ≥95%

Supplier: Van Der Voort Lucht en Milieu Amste

SYN-1111-M001 SYN-1111-M005 SYN-1111-M010
102992-112EA 283.85 USD InStock
102992-112 102992-114 102992-116
AMG-51 ≥95%
AMG-51
c-Met kinase is the receptor for hepatocyte growth factor (HGFR). Primarily expressed on epithelial and mesenchymal cells its normal function is associated with wound healing, liver regeneration and embryo development. However, dysregulation of c-Met through overexpression, gene amplification, mutation or a ligand-dependent autocrine/paracrine loop is associated with tumorigenesis. c-Met dysregulation in human cancer patients is typically associated with a poor prognosis, aggressive disease, increased metastasis and shortened patient survival. Targeting the hepatocyte growth factor/c-Met signalling pathway as a means of cancer therapy has, therefore, become increasingly popular with a number of different therapeutic approaches undergoing clinical trials. AMG-51 represents a modified novel pyrimidone 7 compound that demonstates good effectiveness against c-Met with few off target effects at set concentrations. AMG-51 shows the enzyme selectivity of c-Met with a Ki of 4.9nM, with off target proteins such as IGFR with a Ki of 22nM, Ron with a Ki of 28nM, and KDR with Ki of 139nM.


Formula: C₃₄H₃₃F₂N₅O₅
MW: 629.7 g/mol
Storage Temperature: Freezer
 CAS Number: 890019-63-3
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Specification Test Results
Purity 95%
Appearance/Color Solid.
Solubility Soluble in DMSO.

 

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