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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

Collagenase, Type IV (from Clostridium histolyticum), MP Biomedicals

Supplier: E. Becker & Co. GmbH

0219511090 0219511025 0219511080
IC19511090EA 446.79 USD InStock
IC19511090 IC0219511025 IC0219511080
Collagenase, Type IV (from Clostridium histolyticum), MP Biomedicals
Enzymes
Collagenases degrade native helical collagen fibrils

  • Presentation: Brown Flakey Powder
  • Collagenase Type IV has low tryptic activity
  • Commonly used for islets and other applications where receptor integrity is crucial

Collagenase is used for tissue dissociation combined with other enzymes such as elastase, trypsin, and/or papain.

The material has been tested for Caseinase, Clostripain and Tryptic activities.

Activators: Ca2+ is required.
Inhibitors: Metal chelating agents such as cysteine, EDTA or o-phenanthroline but not DFP. It is also inhibited by a2-macroglobulin - a large plasma glycoprotein. The human skin enzyme is inhibited by human serum but granulocyte collagenase is not. Human serum contains a2-macroglobulin and a1-antitrypsin that may inhibit certain collagenases.

It has an important role in connective tissue metabolism and is produced by specific cells involved in repairs and remodelling processes.

Collagenase Type IV has low tryptic activity. It is commonly used for islets and other applications where receptor integrity is crucial.


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