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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

Indomethacin

Supplier: E. Becker & Co. GmbH

0219021705 0219021710 0219021725 0219021780 0219021701
IC19021705EA 91.16 USD InStock
IC19021705 IC19021710 IC19021725 IC19021780 IC0219021701
Indomethacin
Indomethacin
Indomethacin, an anti-inflammatory agent, inhibits Cox-1 and Cox-2 (cyclooxygenases) with selectivity for Cox-1 (IC50 of 230 nM) over Cox-2 (IC50 of 630 nM).

  • Anti-inflammatory
  • Adipogenic
  • ligand-activated
  • pKa=4.5 (Lit.)

Additionally, Indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

Inhibitor of cyclooxygenase (prostaglandin H synthase 1 and 2). An anti-inflammatory (by blocking prostaglandin biosynthesis by inhibiting cyclooxygenase), antipyretic and analgesic agent. May help prevent the stimulation of tumor cell growth and the suppression of immune surveillance caused by cyclooxygenase's ability to convert arachidonic acid to pro-inflammatory substances such as prostaglandins. Indomethacin is metabolized by the liver and the metabolites excreted in the urine.

EmM (230 nm)=20.8 (in ethanol), EmM (260 nm)=16.2 (in ethanol), EmM (319 nm)=6.29 (in ethanol),(Lit)

Off-white powder

Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.


Formula: C₁₉H₁₆ClNO₄
MW: 357.80 g/mol
Melting Pt: 152…165 °C
Storage Temperature: Ambient
 MDL Number: MFCD00057095
CAS Number: 53-86-1
UN: 2811
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