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Vitamin B12 (cyanocobalamin) 96.0-102.0% (dried basis) USP, Ph. Eur., BP pH 6.0 (1 g/l, H₂O, 20 °C), SAFC®

Supplier: EMD MILLIPORE - PCS - GPS

5.24950.0010 5.24950.0100
EM5.24950.0010EA 653.39 USD InStock
EM5.24950.0010 EM5.24950.0100
Vitamin B12 (cyanocobalamin) 96.0-102.0% (dried basis) USP, Ph. Eur., BP pH 6.0 (1 g/l, H₂O, 20 °C), SAFC®
Vitamin B12 (cyanocobalamin)
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).

Certificaciones: Corresponds to Ph Eur, BP, USP


Formula: C₆₃H₈₈CoN₁₄O₁₄P
MW: 1355.38 g/mol
Melting Pt: >300 °C
Storage Temperature: Ambient
 MDL Number: MFCD00151092
CAS Number: 68-19-9
EINECS: 200-680-0
Merck Index: 12,10152
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Specification Test Results
Assay (Ph Eur, calculated on dried substance) 96.0 - 102.0 %
Assay (USP, calculated on dried substance) 96.0 - 102.0 %
Identity (IR-spectrum) passes test
Identity (Cobalt) passes test
Identity (HPLC) passes test
Appearance dark-red, crystalline powder or dark-red crystals
Absorption ratio (A 361 nm/278 nm) 1.70 - 1.90
Absorption ratio (A 361 nm/550 nm) 3.15 - 3.40
As (Arsenic) ≤ 3 ppm
Cu (Copper) ≤ 25 ppm
Pb (Lead) ≤ 10 ppm
Zn (Zinc) ≤ 25 ppm
Related substances (HPLC, Ph Eur) ≤ 3 %
Related substances (HPLC, USP, 7ß,8ß-Lactocyanocobalamin) ≤ 1.0 %
Related substances (HPLC, USP, 50-Carboxycyanocobalamin) ≤ 0.5 %
Related substances (HPLC, USP, 34-Methylcyanocobalamin) ≤ 2.0 %
Related substances (HPLC, USP, 32-Carboxycyanocobalamin) ≤ 1.0 %
Related substances (HPLC, USP, 8-Epi-cyanocobalamin) ≤ 1.0 %
Related substances (HPLC, USP, Any other unidentified impurity) ≤ 0.5 %
Related substances (HPLC, USP, Total impurities) ≤ 3.0 %
Acetone (HS-GC) ≤ 5000 ppm
Other residual solvents (ICH Q3C) excluded by production process
Loss on drying (Ph Eur) ≤ 12.0 %
Loss on drying (USP) ≤ 12.0 %

 

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