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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

Methotrexate 98-102%, orange powder USP

Supplier: E. Becker & Co. GmbH
Danger

0210229910 0210229925 0210229980 0210229990
IC10229910EA 49.33 USD InStock
IC10229910 IC10229925 IC10229980 IC10229990
Methotrexate 98-102%, orange powder USP
Methotrexate
Folic Acid antagonist; structurally similar to folic acid. Methotrexate is a mixture of 4-amino-10-methylfolic acid and closely related compounds.

A potent anticancer agent. Blocks DNA synthesis by blocking the production of tetrahydrofolate cofactors required for the synthesis of thymidine. Methotrexate is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folypolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Methotrexate-polyglutamate is degraded intracellularly by gamma-glutamyl hydrolase.

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites. Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.

Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis.

Soluble in alkaline solutions with decomposition. Insoluble in water, ethanol, chloroform and ether.


Formula: C₂₀H₂₂N₈O₅
Boiling Pt: 184…204 °C (dec.)
Storage Temperature: Refrigerator
 MDL Number: MFCD00150847
CAS Number: 59-05-2
UN: 2811
ADR: 6.1,III
https://qa.digitalassets.avantorsciences.com/adaptivemedia/rendition?id=d252da573eb32acfcf9e3679268c4a4d3cdb81ae&vid=d252da573eb32acfcf9e3679268c4a4d3cdb81ae&prid=web&clid=SAPDAM
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Specification Test Results
Identity Test A Passes
Identity Test B Passes
Specific Rotation (anhydrous basis) +19° to +24°
Water ≤12%
Residue on Ignition ≤0.1%
Methotrexate Content
(anhydrous basis as
C20H22N8O5)		 98 - 102%

 

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