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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

Tris(hydroxymethyl)aminomethane (TRIS, Trometamol) ≥99% USP, Multi-Compendial for DNA extraction, for biochemistry

Supplier: AVANTOR PERFORMANCE MATERIALS US
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Management of Change (MOC) category = R

4102-F7 4102-F9 4102-01 4102-05 4102-07 4102-09 4102-F8 4102-06
JT4102-F7EA 4300.31 USD InStock
JT4102-F7 JT4102-F9 JT4102-1 JT4102-5 JT4102-7 JT4102-9 JT4102-F8 JT4102-06
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol) ≥99% USP, Multi-Compendial for DNA extraction, for biochemistry
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol)
TRIS (tromethamine) is a commonly used buffer that many suppliers just test to USP specifications. J.T.Baker® tromethamine is cGMP-manufactured at a commercial scale in an FDA registered facility and meets USP requirements, EP specifications, and additional stringent ULTRAPURE BIOREAGENT criteria.


Formula: NH₂C(CH₂OH)₃
Boiling Pt: 357 °C (1013 hPa)
Melting Pt: 169…172 °C
Density: 1.328 g/cm³ (20 °C)
Storage Temperature: Ambient
 MDL Number: MFCD00004679
CAS Number: 77-86-1
EINECS: 201-064-4
Merck Index: 13,09842
https://qa.digitalassets.avantorsciences.com/adaptivemedia/rendition?id=11a03d1ab6b2c11b9a2c83f0a73fc4264cec0110&vid=b84ca1743f9dfe50eb47c249460ab41a6772ceb2&prid=web&clid=SAPDAM
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Specification Test Results
Meets JPC (1997) Chemical Specifications
Meets B.P. Chemical Specifications
Meets E.P. Chemical Specifications
Meets U.S.P Requirements
GMP Manufactured Product
CAUTION: For Manufacturing, processing or repackaging
Bulk Pharmaceutical Chemical
USP - Assay (C₄H₁₁NO₃) 99.0 - 101.0 %
USP - Identification A Passes Test
USP - Identification B Passes Test
USP - Identification C Passes Test
USP - pH (1 in 20) 10.0 - 11.5
USP - Loss on Drying ≤1.0 %
USP - Residue on Ignition ≤0.1 %
USP - Melting Range(Lower) 168 - 172 °C
USP - Melting Range(Upper) 168 - 172 °C
EP/BP - Assay (C₄H₁₁NO₃) (dried basis) 99.0 - 100.5 %
EP/BP - Identification B (melting point) 168 - 174 °C
EP/BP - Identification C Passes Test
EP/BP - Appearance of Solution Passes Test
EP/BP - pH 10.0 - 11.5
EP/BP - Related Substances ≤1.0 %
EP/BP - Chloride (Cl) ≤100 ppm
EP/BP - Iron (Fe) ≤10 ppm
EP/BP - Loss on Drying at 105°C ≤0.5 %
EP/BP - Ash (sulfated) ≤0.1 %
JPC 1997 - Assay (C₄H₁₁NO₃) (dried basis) ≥99.0 %
JPC 1997 - Identification A Passes Test
JPC 1997 - Identification B Passes Test
JPC 1997 - pH 10.3 - 10.7
JPC 1997 - Melting Point 168 - 172 °C
JP - Clarity and Color of Solution Passes Test
JPC 1997 - Heavy Metals (as Pb) ≤8 ppm
JPC 1997 - Arsenic (As) ≤1.6 ppm
JPC 1997 - Loss on Drying ≤0.5 %
JPC 1997 - Residue on Ignition ≤0.10 %
Assay (C₄H₁₁NO₃) (dried basis) ≥99.9 %
Absorbance of a 1M Solution - 260 nm ≤0.06
Absorbance of a 1M Solution - 280 nm ≤0.06
Absorbance of a 1M Solution - 400 nm ≤0.01
Endotoxin Concentration (EU/g) ≤2.5
Iron (Fe) ≤1 ppm
Lead (Pb) ≤1 ppm
Ultrapure Bioreagent Specifications
No Class 1,2,3 or other solvents are used or produced in the
manufacturing or purification of the product.
Manufactured exclusively for Avantor Performance Materials, LLC., by BioSpectra, Inc., Stroudsburg, PA
Elemental Impurities (USP 232, EP 5.20) - Information on elemental
impurities for this product is available on the associated Product
Regulatory Data Sheet and elemental impurity profile report.

 

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