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DAF-FM+diacetate
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DAF-FM+diacetate
Catalog Number:
(100279-194)
Supplier:
Indofine Chemical Company
Description:
Rare Organics & BioChemicals 92954-90-0 1gm Fm[degree]C-Tyr-OH 403.5 Room temperature.
Catalog Number:
(76082-794)
Supplier:
Bioss
Description:
FOXO1 is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
FOXO4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
Supplier:
AFG BIOSCIENCE LLC
Description:
Ethyl 2-​acetamido-​3,​4,​6-​tri-​O-​acetyl-​2-​deoxy-​β-​D-​thiogalactopyranoside 98% (by HPLC)
Supplier:
AMBEED, INC
Description:
(Ethylenedithio)diaceticacid, Purity: 98%, CAS Number: 7244-02-2, Appearance: Powder or crystals, Storage: Sealed in dry, Room Temperature, Size: 5g
Catalog Number:
(77691-540)
Supplier:
LGC STANDARDS
Description:
Chlorhexidine diacetate 100 µg/mL in Acetonitrile:Water, Dr. Ehrenstorfer, LGC Standards
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
(+)-Diacetyl-L-tartaric anhydride 97%
Catalog Number:
(10797-256)
Supplier:
Prosci
Description:
Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the type? subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
Catalog Number:
(PAV4023)
Supplier:
Promega Corporation
Description:
Recombinant human FMS (539-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. FMS is a proto-oncogene that encodes the tyrosine kinase transmembrane receptor for colony stimulating factor 1 receptor (CSF1R).
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Manganese(II) acetate, anhydrous 98+%
Supplier:
Spectrum Chemicals
Description:
1,4-Phenylenediacetic Acid, Purity: 98%, Cas Number: 7325-46-4, Molecular Formula: C6H4(CH2CO2H)2, Molecular Weight: 194.19, Synonyms: p-Phenylenediacetic acid, Appearance: Powder, Color: White to tan, Yellowish White, Size: 5g
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Nickel acetate tetrahydrate 99+% for analysis
Supplier:
Thermo Scientific Chemicals
Description:
MDL: MFCD00066961
Beilstein Registry No.: 3732513
Soluble in water, alcohol
Supplier:
Adipogen
Description:
Cell permeable fluorescent probe. Used for site-specific labeling of N-terminal cysteine proteins with the small molecule probes.
Supplier:
Ricca Chemical
Description:
Clear, colorless liquid with a strong vinegar odor.
Catalog Number:
(100279-150)
Supplier:
Indofine Chemical Company
Description:
Rare Organics & BioChemicals 201532-42-5 1gm Fm[degree]C-D-Thi-OH 393.5 Room temperature.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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