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Methyl+(2S,4S)-4-(isobutyryloxy)-2-pyrrolidinecarboxylate+hydroch
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Methyl+(2S,4S)-4-(isobutyryloxy)-2-pyrrolidinecarboxylate+hydroch
Supplier:
MP Biomedicals
Description:
Hydrocortisone, a primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency. Hydrocortisone, known more formally as cortisone (INN, USAN, BAN), is a steroid hormone, produced by the zona fasciculata of the adrenal gland. It is released in response to stress and a low level of blood glucocorticoids.
Supplier:
Enzo Life Sciences
Description:
Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-β-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 β-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 016073-5G , MDL Number: MFCD03453081
Catalog Number:
(101789-204)
Supplier:
Matrix Scientific
Description:
MF=C6H5Bf2O2 MW=157.91 Cas=144025-03-6 MDL=MFCD01318998 100G
Supplier:
Enzo Life Sciences
Description:
Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-β-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 β-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.
Supplier:
Enzo Life Sciences
Description:
Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-ß-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 ß-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.
Supplier:
Thermo Scientific Chemicals
Description:
2',4'-Difluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone, 97%
Supplier:
TCI America
Description:
4-Ethoxy-2,3-difluorophenylboronic Acid, CAS Number: 212386-71-5, Molecular Formula: C8H9BF2O3, Molecular Weight: 201.96, Synonyms: 4-Ethoxy-2,3-difluorobenzeneboronic Acid (contains varying amounts of Anhydride), Size: 1G
Catalog Number:
(101787-150)
Supplier:
Matrix Scientific
Description:
MF=C8H6F2O MW=156.13 Cas=364-83-0 MDL=MFCD00151261 100G
Supplier:
Adipogen
Description:
The kinases called p38 MAP kinases (MAPKs) are intracellular, soluble serine-threonine kinases which belong to a large family of proteins that include the extracellular regulated kinases (ERKs) and c-Jun N-terminal kinases (JNKs). So far four p38 isoforms have been identified, namely p38alpha, p38beta, p38gamma and p38delta, a.k.a. p38-alpha (MAPK14), -beta (MAPK11), -gamma (MAPK12 / ERK6), and -delta (MAPK13 / SAPK4). The ubiquitously expressed s p38alpha has been the most extensively studied and is believed to be the most physiologically relevant in the regulation of the inflammatory response. The role of the three other isoforms is not currently well understood, however their primary sites of expression are known. Similar to p38alpha, p38beta is also ubiquitously expressed, while p38gamma is expressed predominately in skeletal muscle and p38delta is expressed primarily in the lung, kidney, testis, small intestine and pancreas. The small molecule inhibitor VX-702 is a potent p38 kinase family inhibitor that has been studied for its effects on inflammation and the inflammatory response. VX-702 dose-dependently inhibited the production o IL-6, IL-1beta and TNFalpha (IC(50) = 59, 122 and 99ng/ml, respectively), and in anti-platelet aggregation assays, pre-incubation of platelets with VX-702 (1µM)completely or partially inhibited platelet agonist induced p38 activation (IC(50) = 4 to 20nM). More recently VX-702 has been studied as a potential treatment for rheumatoid arthritis (RA). VX-702 appears to be most effective against MAPK14, followed by MAPK11 and the remaining members of the family, however exact in vitro IC(50) values have not been published. However a large amount of data is available for in vitro growth inhibition assays where VX-702 exhibits poptent activity, having low IC(50) values beginning at ~16nM and ending at < 400µM for the numerous cell lines tested.
Supplier:
Matrix Scientific
Description:
MF=C9H6F2O2 MW=184.14 Cas=207981-48-4 MDL=MFCD00061291 5G
Supplier:
Electron Microscopy Sciences
Description:
OCHCH2CH2CH2CHO CAS #111-30-8 Specific Gravity at 20/20[degree]C:1.131 Purified to EM Grade by "all-glass vacuum-distillation." Free from polymers and contaminants. Purity is guaranteed. Sealed under dry nitrogen.
Supplier:
AOB CHEM USA
Description:
4-Bromo-2,6-difluoro-α-methylbenzyl alcohol ≥97%
Supplier:
AOB CHEM USA
Description:
2-Choro-3,5-difluorophenylboronic acid ≥97%
Catalog Number:
(101797-206)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 009767-500MG , MDL Number: MFCD04038753
Supplier:
Adipogen
Description:
PLX4720 is a potent and selective inhibitor of B-Raf V600E with an IC(50) of 13nM. It is equally potent to c-Raf-1 (Y340D and Y341D mutations), and shows 10-fold selectivity for B-Raf V600E over wild-type B-Raf.
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