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(2-Amino-5-chlorophenyl)(2,6-difluorophenyl)methanone
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(2-Amino-5-chlorophenyl)(2,6-difluorophenyl)methanone
Catalog Number:
(10254-118)
Supplier:
Bioss
Description:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
Catalog Number:
(10254-124)
Supplier:
Bioss
Description:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
Catalog Number:
(10254-126)
Supplier:
Bioss
Description:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
Catalog Number:
(101920-248)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 060565-500MG , MDL Number: MFCD15146510
Supplier:
TCI America
Description:
CAS Number: 1878-65-5
MDL Number: MFCD00004332 Molecular Formula: C8H7ClO2 Molecular Weight: 170.59 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Melting point (°C): 81
Catalog Number:
(102893-314)
Catalog Number:
(102894-662)
Catalog Number:
(101924-876)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 062956-500MG , MDL Number: MFCD05667194
Catalog Number:
(76003-038)
Supplier:
Enzo Life Sciences
Description:
Cell-permeable, potent and selective GSK-3β inhibitor.
Supplier:
APOLLO SCIENTIFIC
Description:
1-(4-Chlorophenyl)-5-propyl-1H-pyrazole-4-carboxylic acid
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 044482-1G , MDL Number: MFCD00663991
Supplier:
AMBEED, INC
Description:
(S)-4-(4-((4-Chlorophenyl)(pyridin-2-yl)methoxy)piperidin-1-yl)butanoic acid compound with benzenesulfonic acid (1:1) 98%
Catalog Number:
(TCP1116-025G)
Supplier:
TCI America
Description:
CAS Number: 2128-93-0
MDL Number: MFCD00003079 Molecular Formula: C19H14O Molecular Weight: 258.32 Purity/Analysis Method: >98.0% (GC) Form: Crystal Color: White Boiling point (°C): 245 Melting point (°C): 102
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 058842-1G , MDL Number: MFCD11052415
Catalog Number:
(76671-582)
Supplier:
AMBEED, INC
Description:
4-{4-[(R)-(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl}butanoic acid benzenesulfonate, Purity: 95%, CAS Number: 190730-42-8, Appearance: Solid, Storage: Sealed in dry, 2-8C, Size: 250MG
Catalog Number:
(77402-442)
Supplier:
APOLLO SCIENTIFIC
Description:
2-(4-Chlorophenyl)piperidine hydrochloride
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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