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(2-Amino-5-chlorophenyl)(2,6-difluorophenyl)methanone
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(2-Amino-5-chlorophenyl)(2,6-difluorophenyl)methanone
Catalog Number:
(101825-066)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 027895-500MG , MDL Number: MFCD03420007
Catalog Number:
(101867-538)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 044774-500MG , MDL Number: MFCD00794804
Catalog Number:
(101922-464)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 061686-500MG , MDL Number: MFCD03421297
Catalog Number:
(101842-134)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 036814-500MG , MDL Number: MFCD08719417
Catalog Number:
(101922-462)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 061685-500MG , MDL Number: MFCD03421296
Catalog Number:
(76110-048)
Supplier:
Bioss
Description:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF141 (ring finger protein 141), also known as ZFP26 or ZNF230, is a 230 amino acid protein that contains one RING-type zinc finger. Expressed as two isoforms (isoform 1 and isoform 2) due to alternative splicing events, RNF141 is thought to function as a transcription factor during spermatogenesis. While isoform 2 is expressed in brain, heart, pancreas, kidney and skeletal muscle, isoform 1 is expressed primarily in testis, suggesting that isoform 1 functions during spermatogenesis. In addition, RNF141 is not expressed in azoospermic (infertile) men, further implicating an important role for RNF141 in testis development and male fertility.
Catalog Number:
(76110-046)
Supplier:
Bioss
Description:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF141 (ring finger protein 141), also known as ZFP26 or ZNF230, is a 230 amino acid protein that contains one RING-type zinc finger. Expressed as two isoforms (isoform 1 and isoform 2) due to alternative splicing events, RNF141 is thought to function as a transcription factor during spermatogenesis. While isoform 2 is expressed in brain, heart, pancreas, kidney and skeletal muscle, isoform 1 is expressed primarily in testis, suggesting that isoform 1 functions during spermatogenesis. In addition, RNF141 is not expressed in azoospermic (infertile) men, further implicating an important role for RNF141 in testis development and male fertility.
Catalog Number:
(101831-542)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 031358-500MG , MDL Number: MFCD07407298
Catalog Number:
(101880-906)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 047662-500MG , MDL Number: MFCD05150471
Supplier:
AMBEED, INC
Description:
2-(4-((4-Chlorophenyl)ethynyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, Purity: 95+%, CAS Number: 1315281-10-7, Appearance: Solid, Storage: Sealed in dry, 2-8 C, Size: 5g
Supplier:
AMBEED, INC
Description:
3-(4-Chlorophenyl)prop-2-yn-1-amine, Purity: 97%, CAS Number: 944818-98-8, Appearance: Solid or liquid, Storage: Keep in dark place, Inert atmosphere, 2-8C, Size: 250MG
Catalog Number:
(10254-128)
Supplier:
Bioss
Description:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
Supplier:
AOB CHEM USA
Description:
5-(2-Bromo-6-chlorophenyl)thiazol-2-amine ≥97%
Catalog Number:
(101930-740)
Supplier:
Matrix Scientific
Description:
MF=C16H13Cln2O4 MW=332.75 MDL=MFCD01944400 ,500Mg
Catalog Number:
(10256-594)
Supplier:
Bioss
Description:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
Supplier:
TCI America
Description:
[Anion for the neutral carrier type ion electrode]
CAS Number: 14680-77-4 MDL Number: MFCD00043105 Molecular Formula: C24H16BCl4K Molecular Weight: 496.10 Purity/Analysis Method: >98.0% (HPLC,W) Form: Crystal
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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