5-Nitrothiophene-2-carbonyl+chloride
Catalog Number:
(76120-926)
Supplier:
Bioss
Description:
The formation of the spliceosome includes the assembly of Sm proteins in an ordered manner onto snRNAs. This process is mediated by the survival of motor neuron (SMN) protein, and is enhanced by modification of specific arginine residues in the Sm proteins to symmetrical dimethylarginines (sDMAs). sDMA modification of Sm proteins is catalyzed by the methylosome, a complex comprised of the type II methyltransferase PRMT5 (also designated Jak-binding protein 1, JBP1), pICln, and two novel factors. PRMT5 binds the Sm proteins via their arginine- and glycine-rich (RG) domains, while pICln binds the Sm domains. pICln also acts as an inhibitor of SnRNP assembly by preventing specific interactions between Sm proteins required for the formation of the Sm core. pICln is a highly conserved, ubiquitously expressed protein that localizes primarily to the cytoplasm, and may play a role as a swelling-activated anion channel or a channel regulator in addition to its function in the methylosome. The gene encoding human pICln maps to chromosome 11q14.1.
Catalog Number:
(89084-228)
Supplier:
Ace Glass
Description:
Wedge-shaped PTFE magnetic stir bars are designed to “plow” up sediment for thorough dispersion
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Catalog Number:
(76120-928)
Supplier:
Bioss
Description:
The formation of the spliceosome includes the assembly of Sm proteins in an ordered manner onto snRNAs. This process is mediated by the survival of motor neuron (SMN) protein, and is enhanced by modification of specific arginine residues in the Sm proteins to symmetrical dimethylarginines (sDMAs). sDMA modification of Sm proteins is catalyzed by the methylosome, a complex comprised of the type II methyltransferase PRMT5 (also designated Jak-binding protein 1, JBP1), pICln, and two novel factors. PRMT5 binds the Sm proteins via their arginine- and glycine-rich (RG) domains, while pICln binds the Sm domains. pICln also acts as an inhibitor of SnRNP assembly by preventing specific interactions between Sm proteins required for the formation of the Sm core. pICln is a highly conserved, ubiquitously expressed protein that localizes primarily to the cytoplasm, and may play a role as a swelling-activated anion channel or a channel regulator in addition to its function in the methylosome. The gene encoding human pICln maps to chromosome 11q14.1.
Supplier:
BeanTown Chemical
Description:
CAS: 2344-80-1; EC No: 219-058-5; MDL No: MFCD00000878
UN No: UN1993; Haz Class: 3; Packing Group: II
Liquid; Linear Formula: (CH3)3SiCH2Cl; Molecular Formula: C4H11ClSi; MW: 122.67
Boiling Point: 98-99°; Flash point: -4°C (25°F)
Density (g/mL): 0.879; Refractive Index: 1.418
Moisture Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 7647-01-0; EC No: 231-595-7; MDL No: MFCD00011324; RTECS: MW4025000
UN No: UN1789; Haz Class: 8; Packing Group: II
Liquid; Molecular Formula: HCl; MW: 36.46
Boiling Point: <gt/>100°
Density (g/mL): 1.19
Supplier:
BeanTown Chemical
Description:
CAS: 676-97-1; EC No: 211-634-4; MDL No: MFCD00002071; RTECS: TA1840000
UN No: UN2928; Haz Class: 6.1 (8); Packing Group: II
Crystalline; Linear Formula: CH3P(O)Cl2; MW: 132.92
Melting Point: 28-34°; Boiling Point: 163°; Flash point: 110°C (230°F)
Density (g/mL): 1.468
Moisture Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 7647-01-0; EC No: 231-595-7; MDL No: MFCD00011324; RTECS: MW4025000
UN No: UN1789; Haz Class: 8; Packing Group: II
Liquid, double distilled in quartz; Molecular Formula: HCl; MW: 36.46
Boiling Point: <gt/>100°
Density (g/mL): 1.19
Supplier:
BeanTown Chemical
Description:
CAS: 15469-38-2; EC No: 232-002-4; MDL No: MFCD00149718
UN No: UN3260; Haz Class: 8; Packing Group: II
Crystalline; Linear Formula: FeF3·3H2O; MW: 166.89
Hygroscopic
Supplier:
Strem Chemicals Inc
Description:
Metallocenes, Derivatives & Cp Precursors
Catalog Number:
(102965-322)
Supplier:
Cell Biolabs
Description:
OxiSelect™ Ferric Reducing Antioxidant Power (FRAP) Assay Kit is a quantitative assay for measuring the antioxidant potential within various samples
Catalog Number:
(89154-424)
Supplier:
Enzo Life Sciences
Description:
The GST Family
Glutathione S-transferases (GSTs) are a large multigen family of multifunctional enzymes, which play an important role in detoxification of potentially genotoxic chemicals, by catalyzing the conjugation of glutathione to a large number of hydrophobic and electrophilic compounds, including carcinogens. They also bind to a variety of nonsubstrate ligands. The GSTs are widely distributed in mammalian species and can be grouped into four classes, based on their biochemical, immunological and structural properties: alpha, mu, pi and theta. GSTs are dimeric, mainly cytosolic, enzymes that have extensive ligand binding properties in addition to their catalytic role in detoxification. A separate microsomal class of GSTs exists which is quite distinct from the cytosolic GSTs, and is designated as "membrane-associated proteins in eicosanoid and glutathione metabolism" (MAPEG). The N-terminal region tends to be better conserved within classes as it includes an important part of the active site.GSTs are believed to play a role in cancer prevention, as the electrophilic compounds that are conjugated to glutathione could otherwise react with and modify cellular components such as DNA, thereby initiating carcinogenesis. On the other hand, GSTs might detoxify chemotherapeutic drugs in cancer cells, thus contributing to drug resistance. In summary, GSTs are a group of enzymes which are centrally involved in drug metabolism and detoxification. Because of their role in detoxification, they have been implicated in drug sensitivity and resistance. They may also influence mutagenesis and carcinogenesis and thus, increased GST activity may become a useful cancer marker. Since many GST genes are polymorphic, there has been considerable interest in determining whether particular allelic variants are also associated with an increase of risk for certain diseases. Glutathione S-transferase-Pi The GST-Pi class (phase II detoxification enzymes) is the most abundant of the human glutathione S-transferases family, a major group of detoxification enzymes and widely distributed in the human body. In normal human tissues, the enzymes protect cells against reactions with glutathione and reactive oxygen species by reducing organic hydroperoxides via gluthathione peroxidase activity. The role of GST-Pi in tumor growth and progression is less well known. It is reported to be variably expressed in breast cancer and is associated with estrogen receptor levels expressed by the tumor. Down-regulation of GST-Pi activity in a study done on a T cell line appears to favor apoptosis and inhibition of GST-Pi function induces apoptosis in rat hepatoma cells. The importance in cancer research is clear, as GST-Pi has been implicated in protection against apoptosis and also suggested to have a role in jun kinase inhibition. The majority of human tumor cell lines express significant amounts of class pi GST, which is why it is being investigated as a potential marker for various types of cancer. GST-Pi is thought to be associated with increased resistance to anticancer drugs. GST-Pi expression is under investigation as a prognostic indicator for resistance to chemotherapy and a marker of treatment resistance.
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
2-Hydroxycyclohexanone dimer 90+%
Supplier:
TCI America
Description:
Methylcyclopentadiene Dimer (so called) (stabilized with BHT), Form: Liquid, Clear, Color: Colorless - Yellow, Size: 100ML
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Acetoin dimer 96%
Supplier:
AMBEED, INC
Description:
Dicarbonylcyclopentadienylruthenium dimer, Purity: 98%, CAS Number: 12132-87-5, Appearance: Solid, Storage: Inert atmosphere, 2-8 C, Size: 250mg
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