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(3,5-Difluorophenyl)(1-piperazinyl)methanone
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(3,5-Difluorophenyl)(1-piperazinyl)methanone
Catalog Number:
(103284-508)
Supplier:
Novus Biologicals
Description:
The U2AF35 Antibody from Novus Biologicals is a rabbit polyclonal antibody to U2AF35. This antibody reacts with human, mouse, rat. The U2AF35 Antibody has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(75932-844)
Supplier:
Rockland Immunochemical
Description:
The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors (1,2). Recent studies have shown that lysosomal biogenesis is regulated by TFEB (3), which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1 (4). Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes (5).
Catalog Number:
(103259-888)
Supplier:
Southern Biotechnology
Description:
In the mouse, CD8 exists in two forms – (i) a CD8 heterodimer composed of an α chain (CD8α) and a β chain (CD8β); and (ii) a homodimer of two α chains. The heterodimer is found on the surface of essentially all thymocytes and the “suppressor/cytotoxic” subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8α without CD8β. It has been suggested that CD8+β- T cells mature extrathymically, while development of the CD8α+β+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8α+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2.
Catalog Number:
(10261-204)
Supplier:
Bioss
Description:
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.
Supplier:
BeanTown Chemical
Description:
CAS: 363-58-6; MDL No: MFCD00041540
UN No: UN1760; Haz Class: 8; Packing Group: III
Liquid; Molecular Formula: C6H6ClF3O3; MW: 218.56
Boiling Point: 67-71°/35 mmHg; Flash point: 67°C (153°F)
Density (g/mL): 1.39
Supplier:
Biotium
Description:
This antibody recognizes a protein of HMW, identified as mucin 3 glycoprotein (MUC3). Its epitope localizes between aa SITTTE. This MAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC2. MUC3 is distributed in colon and rectum, and is also present to a lesser extent in breast, lung and salivary gland tissues. The Mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs) encoded by 60 base pairs (Mucin 1), 69 base pairs (Mucin 2) and 51 base pairs (Mucin 3). The number of repeats is highly polymorphic and varies among different alleles. Mucin 1 proteins are expressed as type I membrane proteins in addition to secreted forms. Mucin 1 is aberrantly expressed in epithelial tumors including breast carcinomas. Mucin 2 coats the epithelia of the intestines and airways and is associated with colonic tumors. Mucin 3 is a major component of various mucus gels and is broadly expressed in normal and tumor cells.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Catalog Number:
(103259-894)
Supplier:
Southern Biotechnology
Description:
In the mouse, CD8 exists in two forms – (i) a CD8 heterodimer composed of an α chain (CD8α) and a β chain (CD8β); and (ii) a homodimer of two α chains. The heterodimer is found on the surface of essentially all thymocytes and the “suppressor/cytotoxic” subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8α without CD8β. It has been suggested that CD8+β- T cells mature extrathymically, while development of the CD8α+β+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8α+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2.
Catalog Number:
(76237-150)
Supplier:
Rockland Immunochemical
Description:
Mouse Interleukin-12(p70) AccuSignal ELISA Kit
Catalog Number:
(102994-724)
Supplier:
Eagle Biosciences
Description:
Human IL-22 ELISA detects human IL-22 concentrations in cell culture supernates, serum, and plasma.
Supplier:
GE Healthcare - Whatman
Description:
These 934-AH™ RTU grade filter papers have been pre-washed, dried (or ignited), cooled, desiccated, and weighed. This eliminates the pre-treating steps that are otherwise required by the US EPA Laboratory Standard Method 2540 parts C, D, and E.
Catalog Number:
(TCM0883-25G)
Supplier:
TCI America
Description:
CAS Number: 35386-24-4
MDL Number: MFCD00005958 Molecular Formula: C11H16N2O Molecular Weight: 192.26 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Flash Point (°C): 112 Freezing point (°C): 35
Supplier:
PORTWEST LLC.
Description:
Perfect for warm weather the RT22 has a stylish contrasting grey collar ensuring dirt and stains are less noticeable.
Catalog Number:
(103328-812)
Supplier:
Novus Biologicals
Description:
The IFI35 Antibody (3H6) from Novus Biologicals is a mouse monoclonal antibody to IFI35. This antibody reacts with human. The IFI35 Antibody (3H6) has been validated for the following applications: Western Blot, ELISA.
Supplier:
Tonbo Biosciences
Description:
The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.
Catalog Number:
(103287-002)
Supplier:
Novus Biologicals
Description:
The ZNF362 Antibody from Novus Biologicals is a rabbit polyclonal antibody to ZNF362. This antibody reacts with human. The ZNF362 Antibody has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Supplier:
Cannon
Description:
The Cannon Four-Bulb Shear Dilution Viscometer Ten Fold Dilution type measures intrinsic viscosities extrapolated to zero shear rate with negligible kinetic energy correction
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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