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Pyrazine-2,6-diamine+hydrochloride
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Pyrazine-2,6-diamine+hydrochloride
Catalog Number:
(10447-400)
Supplier:
Bioss
Description:
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
Catalog Number:
(10354-140)
Supplier:
Bioss
Description:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Catalog Number:
(10462-684)
Supplier:
Bioss
Description:
This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq, Jul 2008]
Catalog Number:
(10456-292)
Supplier:
Bioss
Description:
The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Catalog Number:
(10469-662)
Supplier:
Bioss
Description:
E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.Tissue specificity: Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.
Catalog Number:
(10231-982)
Supplier:
Bioss
Description:
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Catalog Number:
(10474-966)
Supplier:
Bioss
Description:
This gene belongs to the chemokine like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. Alternatively spliced transcript variants encoding different isoforms have been identified.
Catalog Number:
(10664-438)
Supplier:
Bioss
Description:
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
Catalog Number:
(10664-982)
Supplier:
Bioss
Description:
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
Catalog Number:
(10671-732)
Supplier:
Bioss
Description:
AHNAK2 contains 1 PDZ (DHR) domain. There are 3 named isoforms of AHNAK2 produced by alternative splicing. AHNAK2 is a 600-kDa protein composed of a large number of highly conserved repeat segments. AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells.
Catalog Number:
(103294-852)
Supplier:
Novus Biologicals
Description:
The Apolipoprotein E3 / ApoE3 Antibody (960319) [FITC] from Novus Biologicals is a mouse monoclonal antibody to Apolipoprotein E3 / ApoE3. This antibody reacts with human. The Apolipoprotein E3 / ApoE3 Antibody (960319) [FITC] has been validated for the following applications: Western Blot.
Catalog Number:
(103264-490)
Supplier:
Southern Biotechnology
Description:
FITC Anti-Mouse IgG1 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.
Catalog Number:
(10307-496)
Supplier:
Bioss
Description:
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
Catalog Number:
(10233-470)
Supplier:
Bioss
Description:
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro (By similarity).
Supplier:
Biolegend
Description:
FITC anti-human CD62L [DREG-56]; Isotype: Mouse IgG1, κ; Reactivity: Human, Cross-Reactivity: Chimpanzee, Cattle (Bovine, Cow); Apps: FC; Size: 100 μg
Catalog Number:
(102113-296)
Supplier:
Novus Biologicals
Description:
The CD79B Antibody (HM79-11) [FITC] from Novus Biologicals is a armenian hamster monoclonal antibody to CD79B. This antibody reacts with mouse. The CD79B Antibody (HM79-11) [FITC] has been validated for the following applications: Flow Cytometry.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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