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(4-(Bromomethyl)phenyl)acetic+acid
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(4-(Bromomethyl)phenyl)acetic+acid
Catalog Number:
(10304-184)
Supplier:
Bioss
Description:
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097).
Catalog Number:
(TCD0214-25G)
Supplier:
TCI America
Description:
CAS Number: 91-13-4
MDL Number: MFCD00000175 Molecular Formula: C8H8Br2 Molecular Weight: 263.96 Purity/Analysis Method: >98.0% (GC) Form: Crystal Boiling point (°C): 140 Melting point (°C): 93
Supplier:
Adipogen
Description:
Potent member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Analog of ecdysone with similar properties to ponasterone A. Inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Induces apoptosis in cells transfected with wild-type Bax. Induces expression of beta-galactosidase. Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells. Insect steroid hormone involved in regulating metamorphosis, causing a response to G2 cell cycle arrest. Major molting hormone in some insects. Has protective effects in plants.
Catalog Number:
(102542-152)
Supplier:
Matrix Scientific
Description:
MF=C7H6BRNO2 MW=216.04 CAS=3958-60-9 MDL=MFCD00007184 100G
Supplier:
TCI America
Description:
CAS Number: 32247-96-4
MDL Number: MFCD00009905 Molecular Formula: C9H5BrF6 Molecular Weight: 307.03 Purity/Analysis Method: >96.0% (GC) Form: Clear Liquid Boiling point (°C): 140 Flash Point (°C): 26 Freezing point (°C): 18 Specific Gravity (20/20): 1.67
Supplier:
Thermo Scientific Chemicals
Description:
2-Bromo-3-fluorobenzyl bromide, Purity: 98%, Cas number: 1184918-22-6, Molecular formula: C7H5Br2F, Color: Off-white, Form: Solid, 5G
Supplier:
TCI America
Description:
CAS Number: 159689-88-0
MDL Number: MFCD00061271 Molecular Formula: C8H6BrF3O Molecular Weight: 255.03 Purity/Analysis Method: >97.0% (GC) Form: Clear Liquid Color: Colorless Boiling point (°C): 179 Flash Point (°C): 89 Specific Gravity (20/20): 1.58
Supplier:
Matrix Scientific
Description:
MF=C9H9BRO MW=213.08 CAS=619-41-0 MDL=MFCD00000203 100G
Supplier:
Thermo Scientific Chemicals
Description:
Chlorinating, sulfonating, and chlorosulfonating agent
Supplier:
Thermo Scientific Chemicals
Description:
10g CAS: 655-15-2, MDL: MFCD00278796
Supplier:
Matrix Scientific
Description:
MF=C8H6Brno3 MW=244.05 Cas=99-81-0 MDL=MFCD00007356 100G
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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