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(4-Chloro-2-fluoro-3-methylphenyl)cyclopropylmethanone
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(4-Chloro-2-fluoro-3-methylphenyl)cyclopropylmethanone
Supplier:
AOB CHEM USA
Description:
2-Bromo-6-chloro-4-fluoro-3-methylaniline 97
Supplier:
Adipogen
Description:
Inhibitor of pan-Trk activity (IC(50) = 8 and 12nM for TrkA and TrkB). Shown to target Trk (tropomyosin receptor kinase) ATP binding cleft and an immediately adjacent hydrophobic pocket. Preferentially arrests the proliferation of Ba/F3 cells fused with Tel-TrkA, Tel-TrkB and Tel-TrkC (IC(50) = 11, 9 and 7nM, respectively) and in Ba/F3 and RIE cells expressing both TrkA and NGF (IC(50) = 42 and 17nM, respectively) over Mo7e-c-Kit and Rat-A10-PDGFR (IC(50) = 1 and 0.5µM) and Ba/F3-Tel-KDR and wt-Ba/F3 cells (IC(50) = 3.0 and 5.6µM). Displays ~100-fold greater selectivity among a panel of 59 closely related kinases and in 33 cellular kinase assays. Weakly active against relevant cytochrome P450 isozymes and hERG channel, and exhibit adequate microsomal stability, pharmacokinetic profile and efficacy in mice and rats. Suppresses tumor growth in a mouse RIE-TrkAmNGF xenograft model (50mg/kg, p.o.).
Supplier:
TCI America
Description:
2-Chloro-5-fluoro-3-methylpyridine, CAS Number: 38186-84-4, Purity: 98.0%, Molecular Formula: C6H5ClFN, Molecular Weight: 145.56 g/mol, Synonyms: 2-Chloro-5-fluoro-3-picoline, Physical Form: Solid, Size: 1G
Supplier:
AOB CHEM USA
Description:
Ethyl 2-chloro-5-fluoro-3-(trifluoromethyl)benzoate 95
Supplier:
AOB CHEM USA
Description:
1-Bromo-2-chloro-4-fluoro-5-methoxybenzene 97
Supplier:
AOB CHEM USA
Description:
6-Chloro-2-fluoro-3-methoxy-N-methylbenzamide 97
Supplier:
AOB CHEM USA
Description:
2-Chloro-1-fluoro-4-isopentylbenzene ≥95%
Supplier:
APOLLO SCIENTIFIC
Description:
4-Chloro-2-fluoro-5-iodophenol
Supplier:
AOB CHEM USA
Description:
6-Chloro-2-fluoro-m-cresol ≥97%
Supplier:
AOB CHEM USA
Description:
2-Chloro-4-fluoro-5-methylbenzaldehyde ≥97%
Supplier:
TCI America
Description:
2-Chloro-3-fluoro-5-methylpyridine, Purity: >98.0%(GC), CAS Number: 34552-15-3, Molecular Formula: C6H5ClFN, Molecular Weight: 145.56, Synonyms: 6-Chloro-5-fluoro-3-picoline, Size: 1G
Supplier:
AOB CHEM USA
Description:
3-Chloro-5-fluoro-2-methoxyphenol ≥97% research grade
Supplier:
APOLLO SCIENTIFIC
Description:
4-Chloro-2-fluoro-5-nitrophenol
Supplier:
AOB CHEM USA
Description:
3-Chloro-2-fluoro-6-methoxybezaldehyde ≥97%
Supplier:
AOB CHEM USA
Description:
3-Chloro-4-fluoro-5-methylphenol ≥97%
Catalog Number:
(TS45593-0250)
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
4-Chloro-2-fluoro-1-nitrobenzene 98%
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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