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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

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Description:   1-Boc-3-(bromomethyl)azetidine 95%
Catalog Number: TS45216-0010
Supplier: THERMO FISHER SCIENTIFIC CHEMICALS



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Description:   1-(Bromomethyl)-2-methoxybenzene, Technical Grade
Catalog Number: 77409-302
Supplier: APOLLO SCIENTIFIC



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Description:   3-(Bromomethyl)phenylboronic acid 97%
Catalog Number: TS43060-0010
Supplier: THERMO FISHER SCIENTIFIC CHEMICALS



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Description:   Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Catalog Number: 10319-736
Supplier: Bioss



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Description:   MF=C9H8BRCLO2 MW=263.52 CAS=74733-30-5 MDL=MFCD10566565 1G
Catalog Number: 102546-064
Supplier: Matrix Scientific



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Description:   4-(Bromomethyl)-2-methylpyridine hydrobromide ≥97%
Catalog Number: 77749-510
Supplier: AMBEED, INC


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Description:   4-(Bromomethyl)benzenesulfonyl fluoride ≥95%
Catalog Number: 77622-626
Supplier: AMBEED, INC


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Description:   3-(Bromomethyl)-1-methylpyrrolidine hydrobromide
Catalog Number: 102665-160
Supplier: Matrix Scientific



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Description:   MDL Number: MFCD00001306
Catalog Number: 101779-194
Supplier: Matrix Scientific



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Description:   Ethyl-2-(bromomethyl)benzoate ≥97%
Catalog Number: 102842-084
Supplier: Matrix Scientific



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Description:   (Bromomethyl)triphenylphosphonium bromide 98%
Catalog Number: TS32148-0250
Supplier: THERMO FISHER SCIENTIFIC CHEMICALS



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Description:   2-Bromo-4-(bromomethyl)-1-methylbenzene 95%
Catalog Number: 76830-278
Supplier: AMBEED, INC



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Description:   Methyl 4-(bromomethyl)-3-fluorobenzoate 95%
Catalog Number: 77416-060
Supplier: APOLLO SCIENTIFIC



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Description:   MF=C7H5Br2Cl MW=284.39 Cas=68120-44-5 MDL=MFCD08059101 5G
Catalog Number: 101932-032
Supplier: Matrix Scientific



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Description:   2-(Bromomethyl)-5-nitropyridine > 97%
Catalog Number: 77410-148
Supplier: APOLLO SCIENTIFIC



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Description:   4-(Bromomethyl)-1-fluoro-2-nitrobenzene 98%
Catalog Number: 76773-846
Supplier: AMBEED, INC



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