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(Bromomethyl)cyclobutane
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(Bromomethyl)cyclobutane
Catalog Number:
(101938-436)
Supplier:
Matrix Scientific
Description:
MF=C14H16Brno2 MW=310.20 Cas=220499-13-8 1G
Catalog Number:
(10451-520)
Supplier:
Bioss
Description:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Catalog Number:
(102892-690)
Catalog Number:
(102545-314)
Supplier:
Matrix Scientific
Description:
MF=C9H9BRO MW=213.08 CAS=51229-51-7 MDL=MFCD10001463 250MG
Supplier:
AMBEED, INC
Description:
Methyl 3-bromo-2-(bromomethyl)benzoate, Purity: 95%, CAS Number: 337536-14-8, Appearance: Solid or Semi-solid or liquid or lump, Storage: Inert atmosphere, 2-8 C, Size: 5g
Catalog Number:
(10319-732)
Supplier:
Bioss
Description:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Catalog Number:
(102833-204)
Supplier:
Matrix Scientific
Description:
tert-Butyl-3-(bromomethyl)pyrrolidine-1-carboxylate ≥95%
Catalog Number:
(77622-150)
Supplier:
AMBEED, INC
Description:
Methyl 4-(bromomethyl)-2,3-difluorobenzoate ≥97%
Supplier:
AMBEED, INC
Description:
1-(Bromomethyl)-3-chloro-2-methylbenzene, Purity: 95%, CAS Number: 90369-76-9, Appearance: Colorless to Pale-yellow to Yellow-brown Liquid or Solid, Storage: Inert atmosphere, 2-8 C, Size: 250mg
Catalog Number:
(101919-526)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 060062-1G , MDL Number: MFCD19442217
Catalog Number:
(76788-310)
Supplier:
AMBEED, INC
Description:
4-Bromomethylbenzenesulfonamide, Purity: 96%, CAS Number: 40724-47-8, Appearance: White to Pale-yellow to Yellow-brown Solid, Storage: Inert atmosphere, 2-8C, Size: 250MG
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 047836-1G , MDL Number: MFCD11553056
Supplier:
TCI America
Description:
CAS Number: 1522-92-5
MDL Number: MFCD00021982 Molecular Formula: C5H9Br3O Molecular Weight: 324.84 Purity/Analysis Method: >98.0% (T) Form: Crystal Color: White Boiling point (°C): 131 Melting point (°C): 67
Catalog Number:
(102897-738)
Catalog Number:
(102899-030)
Catalog Number:
(77088-028)
Supplier:
AMBEED, INC
Description:
2-(Bromomethyl)-1H-imidazole hydrobromide 95%
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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