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2-Cyano-3-(4-methylphenyl)acrylic+acid
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2-Cyano-3-(4-methylphenyl)acrylic+acid
Catalog Number:
(77301-742)
Supplier:
AMBEED, INC
Description:
2-Oxa-7-azaspiro[4.5]decane hydrochloride 95%
Supplier:
AMBEED, INC
Description:
(R)-2-amino-3-cyclohexylpropanoic acid 95%
Catalog Number:
(101443-604)
Supplier:
Rigaku Reagents
Description:
Sodium Citrate/ Hydrochloric Acid, Buffer, Rigaku
Catalog Number:
(89156-984)
Supplier:
Enzo Life Sciences
Description:
A novel member of the spiro-piperidine class of M2 proton channel inhibitors similar to BL-1743. Displays increased potency (IC50=0.92µM) compared with amantadine.
Catalog Number:
(76084-286)
Supplier:
Bioss
Description:
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP.
Catalog Number:
(76082-300)
Supplier:
Bioss
Description:
IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2).
Supplier:
AMBEED, INC
Description:
(S)-2-Amino-1,1,1-trifluoropropane hydrochloride 95%
Supplier:
AMBEED, INC
Description:
3,4-Dichlorophenylhydrazinium chloride 98%
Supplier:
SILICYCLE INC.
Description:
SiliaBond is SiliCycle's line of functionalized silica gels for use in organic synthesis.
Supplier:
Adipogen
Description:
Useful for the determination of ESBO in foods with HPLC-MS or GC-MS. ESBO is currently employed as plasticizer and HCl scavenger in PVC products. Vegetable oils are widely used for chemical manipulation because of the high numbers of carbon-carbon double bonds. Through the epoxidation, an epoxide group (which is a more reactive group than a double bond) is added to the soybean oil, transforming it in a good hydrochloric acid scavenger and good plasticizer.
Catalog Number:
(89138-882)
Supplier:
Biotium
Description:
ROX reference dye is used to normalize well-to-well variations that may occur during quantitative, real-time PCR reactions.
Catalog Number:
(101971-316)
Supplier:
MORAVEK BIOCHEMICALS MS
Description:
L-Alanine methyl ester, hydrochloride, [1-14C] ≥98% (by HPLC), MORpure™
Catalog Number:
(77319-298)
Supplier:
AMBEED, INC
Description:
3-Chloro-2-fluorophenylhydrazine hydrochloride 97%
Catalog Number:
(77667-262)
Supplier:
AMBEED, INC
Description:
2-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride ≥98%
Catalog Number:
(77314-532)
Supplier:
AMBEED, INC
Description:
2,2-Difluoropropylamine hydrochloride 97%
Supplier:
AMBEED, INC
Description:
1-Acetylpiperidin-4-amine hydrochloride 95%
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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