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(S)-2-Amino-6-(3-carboxypropanamido)hexanoic+acid
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(S)-2-Amino-6-(3-carboxypropanamido)hexanoic+acid
Catalog Number:
(10268-692)
Supplier:
Bioss
Description:
Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
Catalog Number:
(76072-002)
Supplier:
Prosci
Description:
For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100
Catalog Number:
(RL610-602-002)
Supplier:
Rockland Immunochemical
Description:
Secondary Sheep Anti-IgG (H&L) Reacts with Mouse
Catalog Number:
(RL607-1202)
Supplier:
Rockland Immunochemical
Description:
Secondary Goat Anti-IgG (H&L) Reacts with Hamster
Catalog Number:
(RL609-6202)
Supplier:
Rockland Immunochemical
Description:
Secondary Sheep Anti-IgG (H&L) Reacts with Human
Catalog Number:
(RLP100-0005)
Supplier:
Rockland Immunochemical
Description:
Primary Goat Anti-Peroxidase (PAP) Soluble Complex Reacts with N/A
Catalog Number:
(10397-448)
Supplier:
Bioss
Description:
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222).
Catalog Number:
(75928-306)
Supplier:
Rockland Immunochemical
Description:
Guinea Pig IgG F(ab')2 Fragment
Catalog Number:
(RL710-4920)
Supplier:
Rockland Immunochemical
Description:
Secondary Rabbit Anti-IgG (H&L) Reacts with Mouse
Catalog Number:
(RL607-1002)
Supplier:
Rockland Immunochemical
Description:
Secondary Goat Anti-IgG (H&L) Reacts with Hamster
Catalog Number:
(RL605-709-002)
Supplier:
Rockland Immunochemical
Description:
Secondary Donkey Anti-IgG (H&L) Reacts with Goat
Catalog Number:
(76071-534)
Supplier:
Prosci
Description:
For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100 For FACS starting dilution is: 1:10~50
Catalog Number:
(103264-586)
Supplier:
Southern Biotechnology
Description:
CD45R, also known as B220, a member of the protein tyrosine phosphate family and a major cell surface glycoprotein, represents a restricted form of the CD45 family which primarily recognizes only cells of B-lineage from pro-B cell through mature B lymphocytes and prior to the availability of anti-CD19 monoclonal antibodies was commonly used as a pan B-cell marker. It also reacts with certain activated T cells as well as non-MHC-restricted lytically active lymphokine-activated killer (LAK) cells. In vivo administration of RA3-6B2 has been shown to affect differentiation of both T and B cells in normal mice and reduce the level of anti-DNA antibodies and lymphadenopathies in MRL/lpr mice.
Catalog Number:
(RLP200-0005)
Supplier:
Rockland Immunochemical
Description:
Primary Mouse Anti-Peroxidase (PAP) Soluble Complex Reacts with N/A
Catalog Number:
(10260-002)
Supplier:
Bioss
Description:
Myotubularin and the myotubularin-related proteins (MTMR1-9) belong to a highly conserved family of eukaryotic phosphatases. They are protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as substrates. MTMR family members hydrolyze both Phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2. MTMR2 interacts with MTMR5, an inactive family member that increases the enzymatic activity of MTMR2 and dictates its subcellular localization. Mutations in MTMR2 cause autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1), which is characterized by reduced nerve conduction velocities, focally folded myelin sheaths and demyelination. MTMR3 and MTMR4 can either interact with each other or self associate. MTMR6 regulates the activity of the calcium-activated potassium channel 3.1. MTMR9 regulates the activity of MTMR7 and MTMR8.
Catalog Number:
(10800-708)
Supplier:
Rockland Immunochemical
Description:
Cell division sycle(CDC25) gene product is a protein-tyrosine phosphatase, activates a partially purified p34(cdc2)/cyclin B complex. The cdc25 protein also shares homology with a protein phosphatase with activity against both tyrosine and serine (and thus probably threonine) phosphate residues. CDC25C is expressed predominantly in G2 phase in healer cells. The human gene encodes a protein with a predicted molecular mass of 53,000 daltons whose C-terminal domain shares about 37% sequence identity with the fission yeast cdc25 mitotic inducer. CDC25C gene is mapped to 5q31. This antibody is suitable for researchers interested in cancer research, autoimmune disease, cardiovascular disease, neurodegenerative disease, MAK Kinase Signaling, AKT Signaling, GPCR Signaling, Cell Cycle research, and nuclear receptors and transcription factors.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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