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(Tetrahydropyran-4-yl)methyl+tosylate
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(Tetrahydropyran-4-yl)methyl+tosylate
Catalog Number:
(103523-926)
Supplier:
Invitrogen
Description:
Thermo Scientific Pierce SMCC is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7–9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5–7.5 to form stable thioether bonds. In aqueous solutions, NHS ester hydrolytic degradation is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group, but will slowly hydrolyze and lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugations with these crosslinkers are usually performed at pH 7.2–7.5, with the NHS ester (amine-targeted) reacted before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.
Supplier:
Adipogen
Description:
SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45nM, respectively. SAR131675 dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD, with an IC(50) of about 20nM. SAR131675 was found to be highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. However, it was moderately active on VEGFR-2 with a VEGFR-3/VEGFR-2 ratio of about 10. SAR131675 had no antiproliferative activity on a panel of 30 tumors and primary cells, further showing its high specificity and indicating that SAR131675 is not a cytotoxic or cytostatic agent.
Catalog Number:
(TCA2705-25MG)
Supplier:
TCI America
Description:
CAS Number: 141396-28-3
MDL Number: MFCD00895735
Molecular Formula: C23H36N6O5S
Molecular Weight: 508.64
Purity/Analysis Method: <gt/>99.0% (HPLC)
Form: Crystal
Melting point (°C): 180
Specific rotation [a]20/D: 165 deg (C=0.8, MeOH)
Storage Temperature: 0-10°C
Supplier:
AAT BIOQUEST INC
Description:
The Hoechst stains are a family of fluorescent stains for labeling DNA in fluorescence microscopy.
Supplier:
BeanTown Chemical
Description:
CAS: 3886-70-2; EC No: 223-425-5; MDL No: MFCD00064114
UN No: UN2922; Haz Class: 8 (6.1); Packing Group: III
Liquid; Molecular Formula: C12H13N; MW: 171.24
Boiling Point: 153°/11 mmHg; Flash point: <gt/>110°C (<gt/>230°F)
Density (g/mL): 1.067; Refractive Index: 1.623; Optical Rotation: [α]20/D +55°, c = 2 in ethanol
Air Sensitive
Catalog Number:
(BT139260-25G)
Supplier:
BeanTown Chemical
Description:
CAS: 63675-74-1; EC No: 264-408-2; MDL No: MFCD02083138
Solid; Molecular Formula: C16H14O2S; MW: 270.35
Melting Point: 191-197°
Supplier:
ALADDIN SCIENTIFIC
Description:
Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Target: NRTIs; HBV Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection [1-3]. Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV[3, 4]. Catalyst employed in the Sharpless Asymmetric Dihyroxylation of (E,E)- or (E,Z)-1,3-dienoates.1 Also used in the preparation of ?-hydroxy-γ-lactones from ?,γ-unsaturated esters.2Product Introduction:Adefovir dipivoxil, an adenosine analogue, is an oral proagent of the nucleoside reverse transcriptase inhibitor Adefovir. Adefovir dipivoxil inhibits both the wild type and HBV Lamivudine-resistant strains. Adefovir dipivoxil shows anti-orthopoxvirus activity.
Supplier:
TCI America
Description:
CAS Number: 1656-94-6
MDL Number: MFCD00038043 Molecular Formula: C12H13N3 Molecular Weight: 199.26 Purity/Analysis Method: >97.0% (GC) Form: Clear Liquid Specific Gravity (20/20): 1.12
Supplier:
AMBEED, INC
Description:
4-(4-Methylpiperazin-1-yl)benzoic acid 95%
Supplier:
Adipogen
Description:
Antibiotic. Shows antiviral, antifungal and antitumor properties. Immunosuppressive drug used to prevent rejection in organ transplantation, rheumatoid arthritis, and psoriasis. Potent reversible inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), leading to depletion of GMP and interruption of the de novo synthesis of purine nucleotides necessary for B and T lymphocyte proliferation. Inhibits the type II IMPDH isoform (IMPDH-2) 5-fold more potently compared to type I isoform. Inhibits RNA and DNA synthesis. Inducible nitric oxide synthase (iNOS/NOS II) inhibitor. Apoptosis and necrosis inducer. Novel type of inhibitor against RNA guanylyltransferases. Inhibits TNF-alpha-stimulated MAPK/NF-kappaB and ROS generation.
Supplier:
MP Biomedicals
Description:
Storage: Store at Room Temperature (15-30 °C). Protect from light.
Folic acid, also known as folate, is a B vitamin that can be found in a variety of fruits and vegetables. It can also be chemically synthesized. Folate, a watersoluble vitamin, helps the body form red blood cells and aids in the formation of genetic material within every body cell. Folic Acid is a hematopoietic vitamin present, free or combined with one or more additional molecules of L- (+)-glutamic acid, in liver, kidney, mushrooms, spinach, yeast, green leaves, and grasses. A nutritional delivery form of folate. Folic acid and its derivatives are essential mediators of one-carbon metabolism within cells.
Supplier:
TCI America
Description:
CAS Number: 51-55-8
MDL Number: MFCD00022622 Molecular Formula: C17H23NO3 Molecular Weight: 289.38 Purity/Analysis Method: >99.0% (T) Form: Crystal Melting point (°C): 116
Supplier:
AMBEED, INC
Description:
(4-(Morpholinomethyl)phenyl)methanamine, Purity: 95%, CAS Number: 91271-84-0, Appearance: White to yellow or light-brown to dark-brown powder or crystals, Storage: Keep in dark place, Sealed in dry, 2-8 C, Size: 1g
Supplier:
TCI America
Description:
CAS Number: 5908-99-6
MDL Number: MFCD00077268 Molecular Formula: C17H23NO3 Molecular Weight: 676.82 Purity/Analysis Method: >99.0% (T) Form: Crystal Melting point (°C): 194
Supplier:
AMBEED, INC
Description:
2-Acetyl-3-methylpyrazine 98%
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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