Text Search >
tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
Print…
You Searched For:
9,589 results were found
tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
Supplier:
Adipogen
Description:
Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumor growth was inhibited by Afatinib very effectively with low nanomolar IC(50) values ranging from approximately 6nM to below 500nM.
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 011278-100G , MDL Number: MFCD02093760
Supplier:
Matrix Scientific
Description:
3-CHLORO-2-FLUOROBENZYL ALCOHOL MF=C7H6CLFO MW=160.58 CAS=261723-30-2 MDL=MFCD01631549
Supplier:
Matrix Scientific
Description:
MF=C8H6Clfo MW=172.59 Cas=2923-66-2 MDL=MFCD00042203 5G
Supplier:
Thermo Scientific Chemicals
Description:
H-DL-Phe(4-F)-OH. Grade:98+, Melting Point ca 254*[degree]C. Boiling Point C:NA. C9H10FNO2. 51-65-0. HARMFUL
Supplier:
TCI America
Description:
CAS Number: 446-22-0
MDL Number: MFCD00009893 Molecular Formula: C9H9FO Molecular Weight: 152.17 Purity/Analysis Method: >98.0% (GC) Form: Clear Liquid Flash Point (°C): 79 Specific Gravity (20/20): 1.11
Supplier:
TCI America
Description:
CAS Number: 332-42-3
MDL Number: MFCD03844794 Molecular Formula: C8H8BrF Molecular Weight: 203.05 Purity/Analysis Method: >95.0% (GC) Form: Clear Liquid Boiling point (°C): 102 Flash Point (°C): 93 Specific Gravity (20/20): 1.45
Supplier:
AMBEED, INC
Description:
2',6'-Dichloro-3'-fluoroacetophenone, Purity: 98%, CAS Number: 290835-85-7, Appearance: Solid or liquid, Storage: Sealed in dry, Room Temperature, Size: 25g
Supplier:
AMBEED, INC
Description:
2-Chloro-4-fluorobenzyl alcohol, Purity: 98%, CAS Number: 208186-84-9, Appearance: White to yellow powder or crystals, Storage: Sealed in dry, Room Temperature, Size: 25g
Supplier:
TCI America
Description:
CAS Number: 290835-85-7
MDL Number: MFCD02093760 Molecular Formula: C8H5Cl2FO Molecular Weight: 207.03 Purity/Analysis Method: >97.0% (GC) Form: Clear Liquid Boiling point (°C): 255 Specific Gravity (20/20): 1.40
Supplier:
Adipogen
Description:
AV-412 is a potent dual inhibitor of EGFR and ErbB2 tyrosine kinases, including the mutant EGFR(L858R,T790M), which is clinically resistant to the EGFR-specific kinase inhibitors erlotinib and gefitinib. In enzyme assays assay the compound inhibited the EGFR variants and ErbB2 in the nanomolar range with over 100-fold selectivity compared with other kinases, apart from ABL and FLT1, which were both moderately sensitive to the compound. In cells, AV-412 inhibited autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively. It also inhibited epidermal growth factor (EGF)-dependent cell proliferation with an IC(50) of 100nM. Moreover, AV-412 abrogated EGFR signaling in the gefitinib-resistant H1975 cell line, which harbors a double mutation of L858R and T790M in EGFR. In animal studies using cancer xenograft models, AV-412 (30mg/kg) demonstrated complete inhibition of tumor growth of the A431 and BT-474 cell lines, which overexpress EGFR and ErbB2, respectively.
Catalog Number:
(76652-012)
Supplier:
AMBEED, INC
Description:
N-(4-Fluorobenzyl)-2-((R)-5-(3-methylureido)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-3'-yl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide, Purity: 97%, CAS Number: 1889279-16-6, Appearance: Solid, Storage: Sealed in dry, 2-8C, Size: 25MG
Supplier:
VWR International
Description:
Made with high purity acid and deionized water. Suitable as a titrant.
Supplier:
VWR International
Description:
Made with high purity acid and deionized water. Suitable as a titrant.
Catalog Number:
(BDH7237-1)
Supplier:
VWR International
Description:
Made with high purity acid and deionized water. Suitable as a titrant.
Supplier:
VWR International
Description:
Made with high purity acid and deionized water. Suitable as a titrant.
Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
|
|||||||||
List View
