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Catalog Number:
(10356-790)
Supplier:
Bioss
Description:
The mammalian type I Inteferons (IFN1) are produced in response to viral infection and other inducers. They are divided into alpha and beta subtypes leukocytes and fibroblasts reactivity. The human IFN alphas are encoded by a family of at least 15 different genes, while IFN beta is the unique member of its subtype. There is approximately 50% amino acid homology between the alpha and beta subtypes. Both IFN subtypes are pleiotropic cytokines and have a similar range of biological activities. Differences between alpha subtypes, and between IFN alpha and betas, are in potency and cell type specific activities. In particular, IFN beta elicits a markedly higher antiproliferation response in some cell types such as, embryonal carcinoma, melanoma and melanocytes than do IFN alphas. Higher potency of IFN beta in treatment of multiple sclerosis and certain cancers has been observed. Type I IFNs signal through binding to a common cell surface receptor. Two chains of the receptor, IFNAR1 and IFNAR2, have been identified. Both chains are necessary for function and in the absence of either there is neither high affinity binding nor biological activity. The intracellular portions of the receptor subunits are bound by tyrosine kinases, Jak1 and Tyk2, members of the Janus kinase family. Upon ligand binding these kinases are activated and phosphorylate members of the STAT family of transcription factors, as well as IFNAR1 and 2.
Catalog Number:
(76376-110)
Supplier:
ELECTRON MICROSCOPY SCIENCE
Description:
Swiss made tweezers are designed for gripping wafers. These are for large size wafers, as well as for holding slides in the lab.
Catalog Number:
(103322-932)
Supplier:
Novus Biologicals
Description:
The MPPED2 Antibody from Novus Biologicals is a mouse polyclonal antibody to MPPED2. This antibody reacts with human, rat. The MPPED2 Antibody has been validated for the following applications: Western Blot.
Supplier:
Simport Scientific
Description:
Suitable for hoppers accepting plastic sleeves, these cassettes will load in cassette labeling instruments in one simple operation. The QuickLoad™ sleeve loads directly into the hopper and is ready for printing.
Catalog Number:
(103647-796)
Supplier:
Sino Biological
Description:
Produced in rabbits immunized with purified, recombinant Human Factor XI (rh Factor XI; Catalog#10302-H08H; NP_000119.1; Met 1-Val 625). Total IgG was purified by Protein A affinity chromatography.
Catalog Number:
(10483-874)
Supplier:
Bioss
Description:
GLB1L3 is a 653 amino acid protein belonging to the glycosyl hydrolase 35 family. GLB1L3 exists as three alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 11q25. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.
Catalog Number:
(10268-552)
Supplier:
Bioss
Description:
Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.
Catalog Number:
(76236-240)
Supplier:
Rockland Immunochemical
Description:
Mouse CD5L AccuSignal ELISA Kit
Supplier:
CP Lab Safety
Description:
ECO Funnel® is the ultimate lab safety product for collection of hazardous liquid waste. When securely attached onto an open waste container, it prevents 99.9% of toxic fumes from being released into lab. ECO Funnel is designed to prevent fires caused by ignited vapors as well as spills of hazardous waste from open containers, which helps laboratories stay compliant with local health and safety codes.
Catalog Number:
(103284-040)
Supplier:
Novus Biologicals
Description:
The PGL2 Antibody from Novus Biologicals is a rabbit polyclonal antibody to PGL2. This antibody reacts with human. The PGL2 Antibody has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(103267-936)
Supplier:
Novus Biologicals
Description:
The PINX1 Antibody from Novus Biologicals is a rabbit polyclonal antibody to PINX1. This antibody reacts with human. The PINX1 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.
Catalog Number:
(103259-194)
Supplier:
Novus Biologicals
Description:
The C11orf74 Antibody from Novus Biologicals is a rabbit polyclonal antibody to C11orf74. This antibody reacts with human. The C11orf74 Antibody has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Supplier:
TrippNT
Description:
TrippNT's Two Faced Glove Box Holders install face-forawrd or face-back for two convenient choices to easily access gloves
Catalog Number:
(76108-806)
Supplier:
Bioss
Description:
GLB1L3 is a 653 amino acid protein belonging to the glycosyl hydrolase 35 family. GLB1L3 exists as three alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 11q25. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.
Catalog Number:
(10268-554)
Supplier:
Bioss
Description:
Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol.
Catalog Number:
(10250-974)
Supplier:
Bioss
Description:
Myelin regulatory factor: Consitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832). Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage. Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832).
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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