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2,2\'-Dithiodi(benzoic+acid)
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2,2\'-Dithiodi(benzoic+acid)
Supplier:
Adipogen
Description:
Isozyme selective inhibitor of protein kinase Cbeta (PKCbeta). PKCbetaI and PKCbetaII isozyme inhibitor. Amelioriates diabetic retinopathy, diabetic peripheral neuropathy and diabetic nephropathy. Anti-cancer and anti-angiogenic compound. Suppresses glucose-induced adhesion of human monocytes to endothelial cells. Suppresses ERK1/2 and Akt phosphorylation.
Supplier:
Adipogen
Description:
GDC-0941 is a potent class I PI3 kinase (PI3K) inhibitor. It selectively binds to PI3K isoforms in an ATP-competitive manner. It has an IC(50) of 3nM, and shows slight selectivity toward p110beta (11-fold) and p110gamma (25-fold).
Supplier:
Thermo Scientific Chemicals
Description:
Standard for rating diesel-fuel ignition qualities
Supplier:
Adipogen
Description:
SB-216763 is a potent and selective ATP-competitive GSK-3 inhibitor with an IC(50) of 34.3nM for GSK-3alpha, and similar activity for GSK-3beta.
Catalog Number:
(80055-494)
Supplier:
MilliporeSigma
Description:
A derivative of papaverine that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells
Supplier:
G-Biosciences
Description:
Inhibitor of cysteine proteases & mammalian acetylcholinesterase
Catalog Number:
(10075-446)
Supplier:
Prosci
Description:
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gamma;s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. It has recently been suggested that PKCepsilon regulates the sensitivity of GABAA alpha1beta2gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma2 (Qi et al., 2007)
Supplier:
MP Biomedicals
Description:
Oligomycin is a natural antibiotic isolated from Streptomyces diastatochromogenes, which is a mixture of oligomycins A, B, and C.
Supplier:
MP Biomedicals
Description:
Coomassie Blue R-250 is a triphenylmethane dye used extensively in SDS-PAGE for the analysis of proteins.
Supplier:
MP Biomedicals
Description:
Salinomycin sodium salt is a cationophore that promotes transport of Na<sup>+</sup> and K<sup>+</sup> ions through phospholipid bilayers
Catalog Number:
(101798-512)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 010431-500MG , MDL Number: MFCD00172808
Supplier:
MilliporeSigma
Description:
Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs
Supplier:
Adipogen
Description:
INCB018424 is a JAK inhibitor with an IC(50) values of 2.7nM and 4.5nM, respectively for JAK1 and JAK2.
Supplier:
TCI America
Description:
CAS Number: 1007-15-4
MDL Number: MFCD00042466 Molecular Formula: C8H6BrFO Molecular Weight: 217.04 Purity/Analysis Method: >96.0% (GC) Form: Crystal Boiling point (°C): 240 Melting point (°C): 56 Flash Point (°C): 113
Supplier:
Adipogen
Description:
Potent and highly selective Bruton's tyrosine kinase (BTK) inhibitor. Orally bioavailable and irreversible inhibitor of BTK (IC50 = 0.5 nM) with antineoplastic activity. Binds to and irreversibly inhibits BTK activity, preventing B cell activation and B cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. Shown to inhibit autophosphorylation of BTK (IC50 = 11nM), phosphorylation of PLCgamma (IC50 = 29nM), a substrate of BTK and phosphorylation of ERK (IC50 = 13nM).
Supplier:
Adipogen
Description:
PD173955-Analog1 is a potent c-Src inhibitor with an IC(50) value of 9nM. It is also a weaker inhibitor of PDGFR, FGFR and EGFR with IC(50) values of 130nM, 110nM and 190nM respectively.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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