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N-[2-(Dimethylamino)ethyl]-N-methylguanidinehydroiodide
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N-[2-(Dimethylamino)ethyl]-N-methylguanidinehydroiodide
Catalog Number:
(102988-580)
Supplier:
Adipogen
Description:
Specific histone acetyltransferase Gcn5 inhibitor. Anticancer compound. Pre-mRNA splicing inhibitor. Blocks splicing before the first catalytic steps. Potential anti-inflammatory compound.
Supplier:
Biotium
Description:
Membrane-permeant form of Rhod-2 that can be loaded into cells via incubation. Because of the relatively low water solubility of the AM ester, the mild detergent Pluronic F-127 is often used as a dispersing agent to facilitate dye loading. Rhod-2-AM itself does not bind Ca2+ , but it is readily hydrolyzed to Rhod-2 by endogenous esterases once it enters cells.
Catalog Number:
(77622-364)
Supplier:
AMBEED, INC
Description:
LY-2510924 99+%
Catalog Number:
(103286-828)
Supplier:
Novus Biologicals
Description:
The RelB Antibody from Novus Biologicals is a rabbit polyclonal antibody to RelB. This antibody reacts with human. The RelB Antibody has been validated for the following applications: Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(10070-182)
Supplier:
Prosci
Description:
NF-κ-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-κ-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-κ-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-κ-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-κ-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-κ-B complex which translocates to the nucleus. NF-κ-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-κ-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-κ-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-κ-B complex.
Catalog Number:
(77669-944)
Supplier:
AMBEED, INC
Description:
Salinomycin ≥98%
Supplier:
AMBEED, INC
Description:
(2R,3R)-Butane-2,3-diol, Purity: 98%, CAS Number: 24347-58-8, Appearance: Liquid, Storage: Keep in dark place, Inert atmosphere, Room temperature, Size: 25g
Supplier:
Electron Microscopy Sciences
Description:
The Conventional Immunogold Reagents are the classical conjugates in immuno electron microscopy; they are a good choice when the antigen is abundant and the accessibility of the antigen is relatively good.
Catalog Number:
(10401-680)
Supplier:
Bioss
Description:
The NFKB complex consists of NFKB1 or NFKB2 bound to REL, RELA, or RELB. The NFKB complex is inhibited by I kappa B proteins (NFKBIA, or NFKBIB), which inactivate NF kappa B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I kappa B proteins by kinases (IKBKA, or IKBKB,) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF kappa B complex.
Supplier:
Promega Corporation
Description:
The CytoTox-Fluor Cytotoxicity Assay is a single-reagent-addition, homogeneous, fluorescent assay that measures the relative number of dead cells in cell populations.
Catalog Number:
(10401-676)
Supplier:
Bioss
Description:
The NFKB complex consists of NFKB1 or NFKB2 bound to REL, RELA, or RELB. The NFKB complex is inhibited by I kappa B proteins (NFKBIA, or NFKBIB), which inactivate NF kappa B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I kappa B proteins by kinases (IKBKA, or IKBKB,) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF kappa B complex.
Supplier:
OAKTON INSTRUMENTS MS
Description:
Microprocessor based pH 700 benchtop meter measures pH, mV, relative mV, and temperature.
Supplier:
Electron Microscopy Sciences
Description:
The Conventional Immunogold Reagents are the classical conjugates in immuno electron microscopy; they are a good choice when the antigen is abundant and the accessibility of the antigen is relatively good.
Supplier:
Electron Microscopy Sciences
Description:
The Conventional Immunogold Reagents are the classical conjugates in immuno electron microscopy; they are a good choice when the antigen is abundant and the accessibility of the antigen is relatively good.
Supplier:
TCI America
Description:
CAS Number: 37002-45-2
MDL Number: MFCD00003212 Molecular Formula: C21H26O8S2 Molecular Weight: 470.55 Purity/Analysis Method: >98.0% (HPLC) Form: Crystal Melting point (°C): 93 Specific rotation [a]20/D: -23 deg (C=8.8, CH3CN)
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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