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1-(4-Chloro-2,3-difluorophenyl)ethanol
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1-(4-Chloro-2,3-difluorophenyl)ethanol
Supplier:
TCI America
Description:
CAS Number: 23364-44-5
MDL Number: MFCD00074959 Molecular Formula: C14H15NO Molecular Weight: 213.28 Purity/Analysis Method: >99.0% (GC,T) Form: Crystal Melting point (°C): 144 Specific rotation [a]20/D: 7 deg (C=0.6, EtOH)
Supplier:
Adipogen
Description:
SMI-4a is a novel, ATP-competitive inhibitor of Pim1 kinase (IC(50) of 17nM). It kills a wide range of both myeloid and lymphoid cell lines.
Supplier:
Adipogen
Description:
Vorinostat (SAHA, MK0683, Zolinza) inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC50<lt/> 86 nM). These enzymes catalyze the removal of acetyl groups from the lysine residues of histones proteins. In some cancer cells, there is an overexpression of HDACs, or an aberrant recruitment of HDACs to oncogenic transcription factors causing hypoacetylation of core nucleosomal histones. By inhibiting histone deacetylase, vorinostat causes the accumulation of acetylated histones and induces cell cycle arrest and/or apoptosis of some transformed cells. The mechanism of the antineoplastic effect of vorinostat has not been fully characterized.
Supplier:
Adipogen
Description:
Ponatinib is a potent multi-target inhibitor of Abl, PDGFRalpha, VEGFR2, FGFR1 and Src with IC(50) values of 0.37, 1.1, 1.5, 2.2 and 5.4nM respectively.
Supplier:
AMBEED, INC
Description:
2,3-Dichloropyrido[2,3-b]pyrazine, Purity: 95%, CAS Number: 25710-18-3, Appearance: Solid, Storage: Inert atmosphere, 2-8 C, Size: 100mg
Supplier:
Adipogen
Description:
Potent cyclin-dependent kinase (CDK) 1, 2, 5, and 9 inhibitor. Apoptosis inducer. Inhibits the proliferation of various cancer cell lines. Inhibits cysts formation in culture. Casein kinase 1 (CK1delta/epsilon) and Dyrk1A inhibitor. Down regulates expression of Mcl-1 and MYCN. Neuroprotective in experimental traumatic brain injury. Potential anti-inflammatory compound. Potential antidiabetic compound.
Supplier:
Adipogen
Description:
Cell permeable, irreversible calmodulin antagonist. Acts by covalently binding to a lysine-rich inhibitory site. Inhibits by blocking the activation of the Ca2+/calmodulin-dependent phosphodiesterase. Herbicidal mycotoxin. Phytotoxic, antifungal, antibacterial and nematocidal compound. Anticancer compound. Shown to induce paraptosis-like cell death. Shown to inhibit P-glycoprotein-mediated transport.
Catalog Number:
(80053-430)
Supplier:
MilliporeSigma
Description:
Nitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t¹/₂ = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC50 = 130 nM).
Catalog Number:
(BDH3021-20L)
Supplier:
BDH
Description:
Made with high purity acid and deionized water. Suitable as a titrant.
Supplier:
Promega Corporation
Description:
The ReliaPrep gDNA Tissue Miniprep System provides a complete, ready-to-use method for purification of gDNA from up to 25mg of tissue, a buccal swab, or a 1cm mouse tail snip, obtaining intact gDNA without the use of ethanol washes or precipitations.
Catalog Number:
(10820-346)
Supplier:
VWR International
Description:
VWR* Roller Base for DH models: with 2 locking casters, 2 leveling feet, 23/4 in, Roller Dolly (heavy-duty, powder coated steel base) with dual-wheel, swivel locking casters and levelling feet, supports one or two (stacked) incubators, raises unit 3.0in (7.6cm) off the floor
Supplier:
MP Biomedicals
Description:
Folic acid, also known as folate, is a B vitamin that can be found in a variety of fruits and vegetables. It can also be chemically synthesized. Folate, a watersoluble vitamin, helps the body form red blood cells and aids in the formation of genetic material within every body cell. This product exhibits metal binding properties. Hematopoietic vitamin present, free or combined with one or more additional molecules of L-(+)-glutamic acid, in liver, kidney, mushrooms, spinach, yeast, green leaves, and grasses.
Folic acid (Vitamin B9 and folate) is essential to numerous bodily functions. The human body needs folate to synthesize DNA, repair DNA, and methylate DNA as well as to act as a cofactor in certain biological reactions. It is especially important in aiding rapid cell division and growth, such as in infancy and pregnancy. Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon’ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics). Very slightly soluble in cold water (0.0016 mg/mL at 25 °C), soluble to about 1% in boiling water. Slightly soluble in methanol, appreciably less soluble in ethanol and butanol. Insoluble in acetone, chloroform, ether, benzene. Relatively soluble in acetic acid, phenol, pyridine, solutions of alkali hydroxides and carbonates. Soluble in hot dilute HCl and H2SO4.
Catalog Number:
(80057-004)
Supplier:
MilliporeSigma
Description:
A hormone that has been postulated as the mediator of photic-induced anti-gonadotropic activity in photoperiodic mammals. Counteracts the apoptotic effects of etoposide in bone marrow cells.
Supplier:
Adipogen
Description:
3-Hydroxy-hexanoyl-L-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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