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Catalog Number:
(102552-968)
Supplier:
BioVendor
Description:
Uromodulin (Tamm-Horsfall protein, UMOD) is approx. 85-kDa glycoprotein that is produced in the thick ascending limb of Henle´s loop and early distal convoluted tubules of the nephron. It is a transmembrane protein, which is secreted into the urine through proteolytic cleavage of the glycosylphosphatidylinositol (GPI) anchor. It belongs to the GPI family. Healthy individuals excrete tens of miligrams of uromodulin per day, making in the most abundant protein in the urine. Uromodulin modulates cell adhesion and signal transduction by interacting with cytokines and it inhibits the aggregation of calcium crystals. By reducing calcium oxalate precipitation, uromodulin plays a protective role with respect to renal stone formation as demonstrated by recent studies on THP- deficient mice prone to nephrolithiasis. THP acts as a host defense factor against urinary tract infections induced by uropathogens such as Esherichia coli, Staphylococcus saphrophyticus, Proteus mirabilis and Klebsiela pneumonie. Uromodulin binds to type 1 fimbriae of Escherichia coli and thereby blocks colonization of urothelial cells. Tamm-Horsfall protein interacts with other molecules and cells including IL-1, IL-2, TNF, IgG, neuthrophils, lymphocytes and monocytes. Binding of uromodulin to neutrophils induces synthesis of IL-8, provokes the respiratory burst and degranulation and stimulates chemotaxis and phagocytosis. Recently, genome-wide association studies identified uromodulin as a risk factor for chronic kidney disease and hypertension. Mutations in the Uromodulin gene are associated with three autosomal dominant tubulo-interstitial nephropathies such as familial juvenile hyperuricemic nephropathy (FJHN), medullary cystic kidney disease (MCKD2) and glomerulocystic kidney disease (GCKD). These disorders are characterized by juvenile onset of hyperuricemia, gout and progressive renal failure.
Catalog Number:
(76002-094)
Supplier:
Enzo Life Sciences
Description:
Pyruvate kinase M2 activator.
Supplier:
MP Biomedicals
Description:
HEPES has been used in a wide variety of applications such as cell culture, media formulations, tissue and organ culture, protein assays, protein deposition technique etc.
Supplier:
Thermo Scientific Chemicals
Description:
1g CAS: 129799-08-2, MDL: MFCD01632465
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 046131-1G , MDL Number: MFCD08443960
Supplier:
Matrix Scientific
Description:
MF=C12H24N2O2 MW=228.34 CAS=674792-04-2 MDL=MFCD07772101 5G
Catalog Number:
(77697-275)
Supplier:
LGC STANDARDS
Description:
Piperazine-2,5-dione (Glycine Anhydride), Mikromol, LGC Standards
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 044290-5G , MDL Number: MFCD03791213
Catalog Number:
(77669-372)
Supplier:
AMBEED, INC
Description:
POPSO sesquisodium salt (β,β'-Dihydroxypiperazine-1,4-dipropanesulfonic acid sesquisodium salt) ≥98%
Supplier:
TLC PHARMACEUTICAL STANDARD LTD
Description:
Pharmaceutical Standards, Trimetazidine EP Impurity G (Piperazine)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 047055-500MG , MDL Number: MFCD08689721
Supplier:
Matrix Scientific
Description:
Ethyl-4-{2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl}tetrahydro-1(2H)-pyrazinecarboxylate 95
Supplier:
BeanTown Chemical
Description:
CAS: 163765-44-4; MDL No: MFCD02683205
Crystalline/Solid; Molecular Formula: C10H20N2O2; MW: 200.28
Optical Rotation: [α]/D +16±2°, c = 1 in dioxane
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 029391-5G , MDL Number: MFCD00167971
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 045771-5G , MDL Number: MFCD06659593
Catalog Number:
(77669-276)
Supplier:
AMBEED, INC
Description:
1-Benzhydrylpiperazine ≥98%
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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