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Avantor Services provides a wide range of specialized services and digital solutions to help you solve complex challenges.
We’ve built our reputation on consistent, comprehensive mastery of day-to-day operations, allowing lab, clinical, and production environments to focus their high-value resources on core scientific priorities.
As our customers’ needs have evolved, so have our capabilities. We have become experts in scientific operations, improving performance with sophisticated solutions and providing guidance on best practices.
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Description:
Endogenous agonist at melatonin MT1 and MT2 receptors. Displays antioxidant and antiapoptotic effects in numerous cell types as well as beneficial effects in various neurodegenerative diseases. It protects neuronal cells from amyloid beta-mediated oxidative damage and increases survival in an Alzheimer’s disease transgenic mouse model. Melatonin directly inhibits mitochondrial permeability transition pore (IC50 = 0.8M) and reduced the loss of neurons in a rat model of transient brain ischemia.
Description:
Melatonin, Powder known chemically as N-acetyl-5-methoxytryptamine is a naturally occurring hormone that is found in many animals, plants and microbes. Melatonin is categorized by the FDA as a dietary supplement and is not regulated as a pharmaceutical drug. There have been several studies done on melatonin as a potential treatment of gastro-esophageal reflux disease, cancer, immune disorders, cardiovascular disease, depression, seasonal affective disorder, sleep disorders, sexual dysfunction and insomnia. Results have shown that prolonged release of melatonin produces good results in treating insomnia in the elderly.