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3-(Carboxymethyl)benzoic+acid
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3-(Carboxymethyl)benzoic+acid
Catalog Number:
(10071-452)
Supplier:
Prosci
Description:
Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span
Catalog Number:
(10101-496)
Supplier:
Prosci
Description:
ME1 is a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Supplier:
AMBEED, INC
Description:
(2S,2'S)-1,1'-Bis[(S)-(dimethylamino)phenylmethyl]-2,2'-bis(diphenylphosphino)ferrocene, Purity: 98%, CAS Number: 223725-09-5, Appearance: Solid, Storage: Inert atmosphere, 2-8 C, Size: 100mg
Catalog Number:
(EM8.20159.0100)
Supplier:
AMBEED, INC
Description:
1-Bromo-2,5-bis(trifluoromethyl)benzene 98%
Catalog Number:
(102538-480)
Supplier:
Matrix Scientific
Description:
MF=C8H21NOSI2 MW=203.43 CAS=10416-59-8 MDL=MFCD00008270 100G
Supplier:
AMBEED, INC
Description:
Bis(2-hydroxyethyl)amino tris(hydroxymethyl)methane (BIS-TRIS) 99%
Catalog Number:
(76014-358)
Supplier:
Spectrum Chemicals
Description:
Cumene Hydroperoxide, also known as Cumyl Hydroperoxide, is used as an oxidizing agent.
Supplier:
Strem Chemicals Inc
Description:
CAS #: 13568-40-6. Size: 500g.
Catalog Number:
(10814-278)
Supplier:
Thermo Scientific Chemicals
Description:
Seleno-organic compound that inhibits nitric oxide-induced apoptosis. Potent antioxidant. Protects calcium influx blockage
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Chlorodihydrido[bis[(2-diisopropylphosphino)ethyl]amine]iridium 97%
Catalog Number:
(80058-034)
Supplier:
MilliporeSigma
Description:
A reversible inhibitor of nitric oxide synthase in vitro (IC50 = 2-3uM) and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects. Purity: >98% by TLC. Soluble in water. CAS: 65005-57-4. FW: 275.2. 25mg white solid.
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Tributyl phosphate 99+%
Supplier:
Adipogen
Description:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL-1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3) / ERK2 (MAPK1), p38 (MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases and sepsis. IL-33 facilitates Treg expansion in vitro and in vivo. Recently, IL-33 has been involved in adipocyte differentiation. The biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by its oxidation (formation of two disulfide bridges), resulting in an extensive conformational change that disrupts the ST2 binding site. Mutations at amino acids C208S/C232S protect IL-33 from oxidation and increase its activity.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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