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Catalog Number:
(75930-262)
Supplier:
Rockland Immunochemical
Description:
Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth (1). Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm (2,3).
Catalog Number:
(75931-142)
Supplier:
Rockland Immunochemical
Description:
Wild-type p53 induced phosphatase 1 (WIP1) / protein phosphatase magnesium-dependent 1 delta (PPM1D), a protein identified in the p53 DNA response pathway, is a member of the PP2C family of serine/threonine protein phosphatases which selectively inactivates p38 MAPK and dephosphorylates the ATM/ATR targets, Chk1 and p53 (1,2). Studies have shown that it is overexpressed in human cancers and is involved in the regulation of multiple DNA damage signaling pathways (2,3). PPM1D deletion results in a reduction of T and B cell function and compromised cell division, rendering cells resistant to becoming cancerous and slowing tumor development (4,5).
Catalog Number:
(76194-522)
Supplier:
Prosci
Description:
The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. It is required for normal immune responses. This antibody is specific to the epsilon chain of CD3.
Catalog Number:
(75834-646)
Supplier:
Restek
Description:
These solutions are prepared from a single-source (one-refinery) product
Supplier:
Matrix Scientific
Description:
MF=C10H12Os MW=180.27 Cas=1200-13-1 MDL=MFCD00052713 1G
Catalog Number:
(75834-752)
Supplier:
Restek
Description:
This mix has two components: 3-Nitro-o-xylene (1,000 μg/ml) and 2,3,4,5-Tetrachlorophenol (2,000 μg/ml)
Supplier:
Enzo Life Sciences
Description:
Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.
Supplier:
Adipogen
Description:
Antagonizing the Chk1-mediated cell cycle checkpoints has emerged as an attractive target for anticancer therapy. If Chk1 activity is blocked, DNA-damaged or spindle-disrupted cells would exit cell cycle arrest before full repair and subsequently undergo mitotic catastrophe or cell death. Chk1 inhibitors consequently increase the therapeutic index of DNA-damaging or antimitotic agents as well. PF-0477736 is a selective, potent ATP-competitive Chk1 inhibitor, derived from PF-0394691, inhibits Chk1 (Ki, 0.49nM) and Chk2 (Ki, 47nM) in vitro. In tests, PF-0477736 was identified as a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49nM. PF-0477736 abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin. In xenografts, PF-0477736 enhanced the antitumor activity of gemcitabine in a dose-dependent manner. PF-0477736 combinations were well tolerated with no exacerbation of side effects commonly associated with cytotoxic agents.
Catalog Number:
(200014-080)
Catalog Number:
(SXS-430)
Supplier:
SPEX CERTIPREP LLC
Description:
Single-Component organic standards.
Supplier:
Enzo Life Sciences
Description:
Caspase-3 activator.
Catalog Number:
(101095-078)
Supplier:
TCI America
Description:
[Hydroxyl Protecting Agent]
CAS Number: 14470-28-1 MDL Number: MFCD00000814 Molecular Formula: C20H17ClO Molecular Weight: 308.81 Purity/Analysis Method: >98.0% (HPLC,T) Form: Crystal Melting point (°C): 124 Storage Temperature: 0-10°C
Catalog Number:
(89147-972)
Supplier:
Enzo Life Sciences
Description:
Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ).
Catalog Number:
(103360-886)
Supplier:
Novus Biologicals
Description:
The PRMT6 Antibody from Novus Biologicals is a rabbit polyclonal antibody to PRMT6. This antibody reacts with human, mouse. The PRMT6 Antibody has been validated for the following applications: Western Blot.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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