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5-Methyl-1H-pyrazole-3-carboxylic acid
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5-Methyl-1H-pyrazole-3-carboxylic acid
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 77-85 kDa protein known as transglutaminase II (TGase II). TGase II catalyzes calcium-dependent post-translational modification of proteins by formation of an isopeptide bond within or between polypeptide chains. Different tissue and cell types express varying amounts of tissue transglutaminase.
Supplier:
Diagnostic Biosystems
Description:
This antibody recognizes an epitope located in the amino acid residue 410 to 419 of human oncogene product c-Myc. This antibody reacts with both components of the P62 and P64 c-Myc.
Catalog Number:
(76634-384)
Supplier:
Diagnostic Biosystems
Description:
Epithelial antigen is a cell surface glycoprotein and is broadly distributed in epithelial cells and displays a highly conserved expression in carcinomas. Epithelial antigen has been shown to play an important role as a tumor cell marker in lymph nodes from patients with esophageal carcinoma. Epithelial antigen can be used to distinguish between basal cell and basosquamous carcinomas and squamous cell carcinoma of the skin.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a protein of 28 kDa. Calbindin-D-28K is also known as vitamin D-dependent calcium-binding protein or cholecalcin. Calbindin D-28K has a broad tissue distribution; however, it exhibits a cell type-specific expression pattern. This antibody reacts specifically with calbindin-D-28K in brain and kidney tissues.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a 38 kDa protein. Synaptophysin is an glycoprotein occurring in presynaptic vesicles of neurons in the brain, spinal cord, retina, vesicles of adrenal medulla and in neuromuscular junctions. This antibody reacts with neuroendocrine neoplasms of neural as well as epithelial types.
Supplier:
Diagnostic Biosystems
Description:
The mammaglobin gene was first identified using a differential screening approach directed at the isolation of novel, human breast cancer-associated genes. Mammaglobin-A is highly overexpressed in breast cancer cell lines and primary breast tumors. This pattern of expression is restricted to mammary epithelium and metastatic breast tumors. Thus, mammaglobin-A-specific T cell immune responses may provide an important approach for the design of breast cancer-specific immunotherapy.
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to 46 kDa cytokeratin protein designated cytokeratin 17. It reacts with basal cells in complex epithelia and reacts strongly with squamous cell carcinomas.
Supplier:
Diagnostic Biosystems
Description:
DOG1 is expressed ubiquitously in gastrointestinal stromal tumors irrespective of c-kit or PDGFR alpha mutation status. Reactivity for DOG1 may aid in the diagnosis of gastrointestinal stromal tumors, including PDGFRA mutants that fail to express c-kit antigen, and lead to appropriate treatment with imatinib mesylate, an inhibitor of the c-kit tyrosine kinase.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with an antigen expressed by normal and neoplastic T cells and myeloid lineage cells. It strongly stains T cells in the interfollicular areas of normal lymphoid tissues.
Catalog Number:
(76634-422)
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase, and proteolytic tryptase. Human mast cell chymase is considered to be an important marker of mast cells and is an important mediator of inflammation.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 95 to 100 kDa protein. This antibody recognizes amyloid precursor proteins APP695, APP751 and APP770. Amyloid precursor protein and APP-like proteins are transmembrane glycoproteins with a similar modular domain structure.
Catalog Number:
(76634-084)
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to a 70 kDa protein, which is a potent cytolytic pore-forming protein. Perforin is a specific marker of functionally active cytotoxic T-lymphocytes and natural killer cells. Perforin mediates cytolysis of target cells by membrane damage and apoptosis.
Catalog Number:
(76634-394)
Supplier:
Diagnostic Biosystems
Description:
This antibody is specific to 160 kDa protein known as Factor XIII-A. Factor XIII is a β-globulin found in plasma and is composed of two subunits, Factor XIII-A and Factor XIII-B. Factor XIII-A is the catalytic subunit and is a dimer of M.W. 160 kDa. Factor XIII is a dermal dendrocyte marker and v variable reaction with these types of tumors.
Supplier:
Diagnostic Biosystems
Description:
Myeloperoxidase metabolizes most of the hydrogen peroxide generated by activated phagocytes. This antibody stains strongly with the cytoplasm of myeloid cells. The antibody detects myeloperoxidase found in myeloid cells of acute myeloid leukemia. The myeloperoxidase gene has been localized to chromosome 17.
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a protein of 81 kDa. Ezrin serves as a tyrosine kinase substrate and is phosphorylated in EGF-stimulated cells. Ezrin is a cytoplasmic protein, enriched in microvilli and other cell surfaces. Ezrin has an actin-binding capacity. Ezrin is expressed in epithelial cells but not in mesenchymal cells. Ezrin is also expressed by certain epithelial tumors, such as renal cell adenocarcinomas.
Catalog Number:
(76634-286)
Supplier:
Diagnostic Biosystems
Description:
This antibody reacts with a 100 kDa glycoprotein expressed by endothelial cells and 130 kDa glycoprotein present in platelets. It stains endothelial cells in normal as well as malignant tissues.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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