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Catalog Number:
(10075-642)
Supplier:
Prosci
Description:
Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X Receptors (RXRs) family (RXRalpha, beta and gamma) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
Catalog Number:
(10750-166)
Supplier:
Prosci
Description:
VPS53 Antibody: The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.
Catalog Number:
(10750-164)
Supplier:
Prosci
Description:
VPS53 Antibody: The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.
Catalog Number:
(10749-818)
Supplier:
Prosci
Description:
TRBP1 Antibody: The human trans-activation response (TAR) RNA binding protein 1 (TRBP1) was initially identified as a protein that binds to the HIV-1 TAR RNA and activates the long terminal repeat (LTR) expression in the absence and presence of the viral trans-activator Tat. This binding is enhanced by the presence of co-factors such as elongation factor 1alpha (EF-1alpha ), polypyrimidine tract-binding protein (PTB), and the chaperonin-like protein stimulator of TAR RNA-binding proteins (SRB). TRBP1 may act to disengage RNA polymerase II from TAR during transcriptional elongation if the RNA polymerase stalls at the TAR during transcriptional elongation.
Supplier:
Analytik Jena US
Description:
The innuPREP DOUBLEpure Kit allows efficiently extracting of DNA fragments from TAE or TBE agarose gels, and utilizes a novel 2-step technology for purifying amplification products from PCR reaction mixtures.
Catalog Number:
(82024-256)
Supplier:
GE Healthcare - HyClone
Description:
Trypan Blue solution, 0,4%, is routinely used as a cell stain to assess cell viability using the dye exclusion test.
Catalog Number:
(77507-038)
Supplier:
VWR International
Description:
VWR®, part of Avantor has industry leading Anatomical Pathology reagents available for your lab.
Catalog Number:
(89279-746)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to Na-independent D-amino acid transporter Purity: Affinity purified using antigen. Species Reactivity: Human Mouse Rat Tested Applications: IHC WB Pkg Size: 100 ug
Supplier:
BeanTown Chemical
Description:
CAS: 103-36-6; EC No: 203-104-6; MDL No: MFCD00009189; RTECS: GD9010000
Liquid; Linear Formula: C6H5CH=CHCOOCH2CH3; Molecular Formula: C11H12O2; MW: 176.21
Melting Point: 6-8°; Boiling Point: 271°; Flash point: <gt/>110°C (<gt/>230°F)
Density (g/mL): 1.049; Refractive Index: 1.558
Supplier:
Invitrogen
Description:
Thermo Scientific Pierce Premium Grade Sulfo-SMCC is our highest quality formulation of amine-to-sulfhydryl crosslinker, specially characterized for applications where product integrity and risk minimization are paramount.
Supplier:
MP Biomedicals
Description:
Coomassie Brilliant Blue G-250 is a protein stain in electrophoresis. Brilliant Blue G has been used in the Bradford dye-binding protein assay.
Catalog Number:
(10296-498)
Supplier:
Bioss
Description:
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
Catalog Number:
(103278-508)
Supplier:
Novus Biologicals
Description:
The NDUFB6 Antibody from Novus Biologicals is a rabbit polyclonal antibody to NDUFB6. This antibody reacts with human. The NDUFB6 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin.
Catalog Number:
(10664-562)
Supplier:
Bioss
Description:
p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
Catalog Number:
(76010-618)
Supplier:
Prosci
Description:
The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles. [provided by RefSeq].
Catalog Number:
(103358-824)
Supplier:
Novus Biologicals
Description:
The MBD1 Antibody from Novus Biologicals is a rabbit polyclonal antibody to MBD1. This antibody reacts with human. The MBD1 Antibody has been validated for the following applications: Western Blot.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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