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Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Stachyose hydrate, Technical Grade
Catalog Number:
(103223-210)
Supplier:
Novus Biologicals
Description:
CaM Kinase I, Polyclonal Antibody, Host: Sheep, Species reactivity: human, Isotype: IgG, Immunogen: E. Coli-derived recombinant human CaM Kinase I alpha Ser176-Arg254 (Ala224Ser), synonyms: CaM kinase I alpha, CaM kinase I, Application: WB, IHC, Size: 100UG
Catalog Number:
(220024-726)
Supplier:
R&D Systems
Description:
The Recombinant Mouse CCL3/MIP-1 alpha Protein from R&D Systems is derived from E. coli. The Recombinant Mouse CCL3/MIP-1 alpha Protein has been validated for the following applications: Bioactivity.
Catalog Number:
(103223-248)
Supplier:
Novus Biologicals
Description:
Alpha-Aminoadipate Aminotransferase, Polyclonal Antibody, Host: Sheep, Species reactivity: human, Isotype: IgG, Immunogen: E.coli-derived recombinant human alpha -Aminoadipate Aminotransferase Met1-Leu425, synonyms: KAT2, Application: WB, Size: 25UG
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
L(+)-Isoleucine 99%
Catalog Number:
(76630-056)
Supplier:
Prosci
Description:
Anti-V alpha TCR Recombinant Antibody [Clone: 34]
Supplier:
Enzo Life Sciences
Description:
Synuclein was originally identified in Torpedo californica as a small neuroprotein that localized to the nuclear envelope of neurons and to presynaptic nerve termini. The human homolog was initially termed NACP, a precursor protein to NAC (Non-Ab Component), because of its prevalence in amyloid plaques in Alzheimer’s patients. Later, NACP was recognized as being alpha-Synuclein (alpha-SYN), a 14kDa protein, belonging to the synuclein family of phosphoproteins that also includes: betalpha-SYNuclein, gammalpha-SYNuclein, and synoretin.
alpha-SYN is recognized as a key component in the development and diagnosis of neurodegenerative synucleinopathic diseases (NSDs), such as Alzheimer’s and Parkinson’s disease. In the past five years, several genetic and post-translational modifications to alpha-SYN have been elucidated that have been linked to its collaboration in the formation of the classical Lewy bodies (LBs) or Lewy neurites that are associated with neurodegeneration. A study that shed more light on the neurogenesis of autorecessive synucleinopathies (ARSs) was the finding that alpha-SYN accumulation can occur due to mutations in the E3 ubiquitin ligase. ARSs only account for a small percentage of NSD. Thus the illustration that alpha-SYN has a high susceptibility to tyrosine nitration may be the key component in understanding the formation of LBs. Due to the chemical structure of alpha-SYN, tyrosine nitration readily leads to the formation of oligomers via covalent O,O’-dityrosine bonds (cross-linking). Nitrosylated, wild-type, alpha-SYN products thus form SDS-insoluble, heat-stable aggregates in vitro that may account for alpha-SYN inclusions in all forms of NSDs.
Catalog Number:
(10765-856)
Supplier:
Prosci
Description:
The MAb11 monoclonal antibody specifically reacts with human tumor necrosis factor alpha (TNF-alpha), a 157 amino acid non-glycosylated protein. TNF-alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-alpha is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. The MAB11 antibody was generated from recombinant human TNF and is reported to be a neutralizing antibody.
Supplier:
Advantec MFS
Description:
Advantec Quantitative Ashless Filter Papers are made from the highest quality alpha cotton cellulose.
Supplier:
AMBEED, INC
Description:
D-(-)-Glutamic acid 98%
Catalog Number:
(76959-726)
Supplier:
ANTIBODIES.COM LLC
Description:
Mouse monoclonal [ESR1/3564] antibody to Estrogen Receptor alpha for IHC-P with samples derived from Human.
Catalog Number:
(10300-566)
Supplier:
Bioss
Description:
The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in the targeted degradation of IkB (1). IkB kinase alpha (IKK alpha), previously designated CHUK (2), interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation, serines 32 and 36 (3). IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines (4). Phosphorylation of the IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1 (5). The functional IKK complex contains three subunits, IKK alpha, IKK beta and IKK gamma (also designated NEMO), and each appears to make essential contributions to IkB phosphorylation (6). IKAP (IKK-complex-associated protein) is a protein that acts as a scaffold, interacting with NIK, IKK alpha and IKK beta and assembling them into an active kinase complex (7,8)
Catalog Number:
(220022-599)
Supplier:
R&D Systems
Description:
The Recombinant Pro-TNF-alpha Fusion Protein from R&D Systems is derived from E. coli. The Recombinant Pro-TNF-alpha Fusion Protein has been validated for the following applications: Enzyme Activity.
Supplier:
AMBEED, INC
Description:
4-tert-Butyl-α-chlorotoluene 98%
Catalog Number:
(102115-028)
Supplier:
Novus Biologicals
Description:
Mouse Monoclonal IL4 Receptor alpha Antibody (49/20). Tested Applications: Western Blot, ELISA, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin. Tested Reactivity: Human.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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