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2,2\':5\',2\'\'-Terthiophene-5-carboxaldehyde
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2,2\':5\',2\'\'-Terthiophene-5-carboxaldehyde
Catalog Number:
(89141-478)
Supplier:
Enzo Life Sciences
Description:
The octapeptide circulatory hormone Angiotensin II is a critical regulator of cardiovascular homeostasis formed in blood, with dual function in tissues of the brain, kidney, heart, and vasculature as an autocrine/paracrine growth hormone. The actions of angiotensin II are mediated by type one (AT1) and type two (AT2) angiotensin II receptors, members of the seven-transmembrane Gprotein coupled receptor (GPCR) family. AT1 receptors couple predominantly with Gq/11 alpha subunits, and signal through phospholipases C, D, and A2, inositol phosphates, and calcium channels, as well as a variety of serine/threonine and tyrosine kinases. AT1 expression is greatest in vascular smooth muscle, liver, kidney, adrenal cortex, brain, and lung, and is primarily responsible for the physiological effects of angiotensin II, including regulation of arterial blood pressure, electrolyte and water balance, thirst, hormone secretion, and renal function. The AT2 receptor displays approximately 30% identity to the AT1 receptor, and is highly expressed during embryonic development. AT2 expression in adult tissue is limited to the adrenal medulla, brain, and reproductive tissues, but is upregulated in injured tissue following myocardial infarction, vascular injury, and wound healing. AT2 receptor signaling is not dependent on G-protein coupling or receptor phosphorylation, although coupling to Gia2 and Gia3 alpha subunits occurs in some tissues. AT2 activation can stimulate tyrosine and serine/threonine phosphatases through activation of nitric oxide and cGMP, and appears to counteract the stimulatory effects of AT1 receptor and growth factor receptor signaling.
Supplier:
Argos Technologies
Description:
Argos Technologies® PolarSafe™ Metal Freezer Storage Racks are constructed of high-quality, corrosion resistant stainless steel
Supplier:
TCI America
Description:
(stabilized with K2CO3)
CAS Number: 7252-83-7 MDL Number: MFCD00000213 Molecular Formula: C4H9BrO2 Molecular Weight: 169.02 Purity/Analysis Method: >97.0% (GC) Form: Clear Liquid Boiling point (°C): 150 Flash Point (°C): 52 Specific Gravity (20/20): 1.44
Supplier:
Honeywell Research Chemicals
Description:
Hydroxynaphthol blue, Analytical, indicator for metal titration, CAS: 63451-35-4, Synonym: 1-(2-Hydroxy-4-sulfo-1-naphthylazo)-2-naphthol-3, 6-disulfonic acid trisodium salt, 3-Hydroxy-4-(2-hydroxy-4-sulfo-1-naphthylazo)naphthalene-2, 7-d, Complexometric Reagent, Size: 50G
Catalog Number:
(89288-626)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to SLC22A11 (N-terminal)
Catalog Number:
(TCC1324-5G)
Supplier:
TCI America
Description:
CAS Number: 108448-77-7
MDL Number: MFCD00151762 Molecular Formula: C10H17NO2S Molecular Weight: 215.31 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 182 Specific rotation [a]20/D: 31 deg (C=1, CHCl3)
Catalog Number:
(89358-842)
Supplier:
Genetex
Description:
The DCTN1 gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein. Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one. Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy.
Supplier:
Bachem Americas
Description:
JKC-363 is a highly potent and selective MC4 receptor antagonist.
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Bromocresol green sodium salt, water soluble indicator
Catalog Number:
(10365-512)
Supplier:
Bioss
Description:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].
Catalog Number:
(10365-530)
Supplier:
Bioss
Description:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].
Catalog Number:
(10069-056)
Supplier:
Prosci
Description:
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
Catalog Number:
(TCC0085-25ML)
Supplier:
TCI America
Description:
CAS Number: 97-97-2
MDL Number: MFCD00000948 Molecular Formula: C4H9ClO2 Molecular Weight: 124.56 Purity/Analysis Method: >98.0% (GC) Form: Clear Liquid Boiling point (°C): 130 Flash Point (°C): 35 Specific Gravity (20/20): 1.09
Catalog Number:
(80058-250)
Supplier:
MilliporeSigma
Description:
( {1,3-bis[tris(Hydroxymethyl)methylamino]propane}). White solid. Purity: >98% by titration. Heavy metals: <1 ppm. Soluble in H2O. Absorbance (1.0 M, H2O, 260 nm): <0.08. pKa 6.8 at 20[degree] C. CAS 64431-96-5, M.W. 282.4.
Catalog Number:
(10410-022)
Supplier:
Bioss
Description:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].
Catalog Number:
(10410-014)
Supplier:
Bioss
Description:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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