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2-(Phenoxymethyl)benzoic+acid
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2-(Phenoxymethyl)benzoic+acid
Catalog Number:
(10484-704)
Supplier:
Bioss
Description:
SNAPC3 is part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. SNAPC3 binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. SNAPC3 recruits TBP and BRF2 to the U6 snRNA TATA box.
Supplier:
BeanTown Chemical
Description:
CAS: 152-18-1; MDL No: MFCD00014888
UN No: UN3278; Haz Class: 6.1; Packing Group: III
Liquid; Linear Formula: P(S)(OCH3)3; Molecular Formula: C3H9O3PS; MW: 156.15
Supplier:
BeanTown Chemical
Description:
CAS: 865-49-6; EC No: 212-742-4; MDL No: MFCD00000827
UN No: UN1888; Haz Class: 6.1; Packing Group: III
Liquid; Molecular Formula: CDCl3; MW: 120.38
Melting Point: -64°; Boiling Point: 60.9°
Density (g/mL): 1.5; Refractive Index: 1.444
Light Sensitive, Moisture Sensitive
Supplier:
Adipogen
Description:
Potent, cell permeable, highly specific, reversible PI(3)K (phosphoinositide 3-kinase) inhibitor. pan-class I / II / III PI3K inhibitor. Acts on the ATP-binding site of the enzyme. In solution more stable than wortmannin. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Autophagy inhibitor (autophagosome formation). Inhibitor of BET bromodomain proteins BRD2, BRD3 and BRD4.
Supplier:
MilliporeSigma
Description:
A potent, cell-permeable, and irreversible inhibitor of caspase-8 (MACH, FLICE, Mch5)
Catalog Number:
(77440-244)
Supplier:
Bioss
Description:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of the GRM1 gene have been described but their full-length nature has not been determined.
Catalog Number:
(76203-480)
Supplier:
Enzo Life Sciences
Description:
A selective phosphodiesterase PDE III inhibitor, IC50=0.7µM. Siguazodan is a potent inotropic, vasodilator and antiplatelet agent with sustained duration of action. It synergizes with PDE IV inhibitors (roliprams) in blocking antigen-induced bronchospasm in the guinea pig.
Catalog Number:
(10454-238)
Supplier:
Bioss
Description:
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.
Catalog Number:
(89351-654)
Supplier:
Genetex
Description:
X-ray Repair Cross Complementing (XRCC1) plays a role in excision repair of DNA after ionizing irradiation. XRCC1 binds to DNS ligase III through the C-terminal 96 amino acids and to DNA polymerase beta through the N-terminal half. In testis XRCC1 is expressed at high levels.
Supplier:
Thermo Scientific Chemicals
Description:
32-63 Micron APS Powder, S.A. 200m2/g
Catalog Number:
(10332-654)
Supplier:
Bioss
Description:
Matrix Metalloproteinase 8 (MMP8) is also known as neutrophil collagenase and collagenase 2. MMP8 degrades fibrillar collagens types I, II, III, aggrecan, serpins and alpha 2 macroglobulin. All collagenases cleave fibrillar collagens at one specific site resulting in generation of N terminal three quarter and C terminal one quarter fragments, which then denature to gelatin at body temperature. The substrate specificity of collagenases is variable: MMP1 degrades type III collagen more efficiently than type I or type II collagen, whereas MMP8 is more potent in degrading type I collagen than type III or type II collagen. MMP13, in turn degrades type II collagen 6 fold more efficiently than type I and type II collagens and displays almost 50 fold stronger gelatinolytic activity than MMP1 and MMP8. MMP8 is very similar to MMP1, sharing 57 % amino acid identity. Most cell types do not produce MMP8. Until recently, it was thought that MMP8 was produced exclusively by neutrophils, but it has also been detected in other cell types including arthritic chondrocytes and gingival fibroblasts. The human MMP8 gene has the chromosomal location of 11q22.2-22.3. MMP8 is heavily glycosylated, and the zymogen has a mass of 85 Kd. The zymogen is quickly activated to the 64 Kd form, and this breaks down to a cascade of active forms.
Catalog Number:
(10671-748)
Supplier:
Bioss
Description:
Members of the class-III pyridoxal-phosphate-dependent aminotransferase family, such as AGXT2, catalyze the conversion of glyoxylate to glycine using L-alanine as the amino donor. AGXT2 protects from asymmetric dimethylarginine (ADMA)-induced inhibition in nitric oxide (NO) production. Elevated blood concentrations of ADMA, a methyl derivate of the amino acid arginine and an endogenous inhibitor of nitric oxide (NO) synthase, is produced by the physiological degradation of methylated proteins and is found in association with diabetes, hypertension, congestive heart failure and atherosclerosis. AGXT2L2 (alanine-glyoxylate aminotransferase 2-like 2) is a 450 amino acid pyridoxal phosphate that exists as a homotetramer. Belonging to the class-III pyridoxal-phosphate-dependent aminotransferase family, AGXT2L2 localizes to the mitochondria and exists as three alternatively spliced isoforms. Encoded by a gene located on human chromosome 5q35.3, AGXT2L2 may have similar functions as AGXT2.
Catalog Number:
(10798-010)
Supplier:
Prosci
Description:
Glycophorin-A, a member of the glycophorin-A family, is also known as CD235a and Gypa, which is heavily glycosylated on serine and threonine residues at the N-terminal extracellular domain. CD235a,a single-pass type III membrane protein,is the major intrinsic membrane sialoglycoprotein of the erythrocyte. Also,CD235a appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. Furthermore,CD235a may be involved in translocation of SLC4A1 to the plasma membrane.
Catalog Number:
(10454-308)
Supplier:
Bioss
Description:
Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.
Catalog Number:
(89264-856)
Supplier:
Genetex
Description:
Anti - NTH polyclonal
Supplier:
BeanTown Chemical
Description:
CAS: 1461-25-2; EC No: 215-960-8; MDL No: MFCD00009422; RTECS: WH8605000
UN No: UN2788; Haz Class: 6.1; Packing Group: III
Liquid; Linear Formula: [CH3(CH2)3]4Sn; Molecular Formula: C16H36Sn; MW: 347.17
Melting Point: -97°; Boiling Point: 245-247°; Flash point: 107°C (225°F)
Density (g/mL): 1.057 ; Refractive Index: 1.473
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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