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Methyl+2-amino-3,5-difluorobenzoate
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Methyl+2-amino-3,5-difluorobenzoate
Catalog Number:
(10352-658)
Supplier:
Bioss
Description:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
Catalog Number:
(76083-202)
Supplier:
Bioss
Description:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
Catalog Number:
(JT4001-1)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Crystals. DNase-, RNase-, and protease-free.
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Copper(II) sulphate pentahydrate USP
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Achieve control over laboratory variables -- minimizing variability and maximizing consistency of results -- by relying on salts in a variety of grades - ACS, BAKER, etc.
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Granular. Lot analysis on label.
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Optimize biopharmaceutical fermentation and cell culture productivity and improve the efficiency of your pharmaceutical production and biopharmaceutical processes with our proven-effective vitamins and pharmaceutical process minerals. Both the J.T.Baker® and Macron Fine Chemicals™ brands of vitamins and minerals are available as USP, FCC, NF or ACS certified products.
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Crystals. GMP manufactured. Pyrogen tested.
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
White crystals or granules. Must be subjected to further processing during the preparation of injectable dosage forms. Meets USP and FCC requirements. GMP manufactured product. Preserve in tightly sealed containers.
Supplier:
VWR International
Description:
These flexible and electrostatic-free 4 mm bags qualify as Type II entitled barrier material under MIL-B-81750b.
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Avantor excipients are used during the formulation process in a wide range of applications. Avantor provides high-purity and performance excipients that serve as fillers, binders, disintegrants, lubicants, flavors, emulsifiers and preservatives. All the products are cGMP produced and meet USP grade standards.
Catalog Number:
(JT1846-7)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Cupric Sulfate, 5-Hydrate, U.S.P., Multi-Compendial
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Crystals. GMP manufactured.
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
ACS—Reagents meeting the requirements of the American Chemical Society Committee on Analytical Reagents. The specifications listed in this catalog are based on the ACS Reagent Chemicals Tenth Edition. Â
Supplier:
VWR
Description:
VWR offers salt solutions for common cell culture procedures.A sterile reagent for the preparation of competent cells for transformation.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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