Methyl+2-(2,5-dioxoimidazolidin-4-yl)acetate
Catalog Number:
(75933-594)
Supplier:
Rockland Immunochemical
Description:
The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.
Supplier:
Matrix Scientific
Description:
MF=C13H15No4 MW=249.27 Cas=319470-14-9 250Mg
Supplier:
AMBEED, INC
Description:
Diethyl 2,2-(1,4-phenylene)diacetate, Purity: 98%, CAS Number: 36076-26-3, Appearance: White to light-yellow powder or crystals, Storage: Sealed in dry, Room Temperature, Size: 1g
Catalog Number:
(10072-806)
Supplier:
Prosci
Description:
Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth. Up-regulation of DLL4 expression has been implicated in the vascular development of certain tumors. Recombinant human sDLL4 is a 54.0 kDa glycoprotein containing 498 amino-acid residues.
Supplier:
AMBEED, INC
Description:
1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-(methylamino)piperidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Purity: 98%, CAS number: 127294-70-6, Appearance: White to light-yellow powder or crystals, Storage: Inert atmosphere, Room Temperature, Size: 25MG
Catalog Number:
(102541-566)
Supplier:
Matrix Scientific
Description:
MF=C4H7NO4 MW=133.10 CAS=1783-96-6 MDL=MFCD00063081 100G
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Adipic acid 99%
Supplier:
AMBEED, INC
Description:
2-(2-Chlorophenyl)-2-oxoacetic acid, Purity: 95%, CAS Number: 26118-14-9, Appearance: Powder or crystals, Storage: Sealed in dry, Room Temperature, Size: 1g
Supplier:
AMBEED, INC
Description:
(4-Chloro-3-formylphenyl)boronic acid, Purity: 97%, CAS Number: 2354338-14-8, Appearance: Solid, Storage: Inert atmosphere, 2-8 deg C, Size: 5g
Supplier:
Matrix Scientific
Description:
MF=C7H7Bn2O2 MW=161.96 Cas=338454-14-1 5G
Catalog Number:
(RC9301-4)
Supplier:
Ricca Chemical
Description:
Eriochrome Black T 1% (w/v) in 20% (v/v) triethanolamine / 80% (v/v) isopropyl alcohol for hardness of water determinations
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Catalog Number:
(10664-564)
Supplier:
Bioss
Description:
p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
Catalog Number:
(101921-916)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 061412-500MG , MDL Number: MFCD12197731
Supplier:
AMBEED, INC
Description:
1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid 98%
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