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Catalog Number:
(76082-348)
Supplier:
Bioss
Description:
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.
Supplier:
Adipogen
Description:
Aminopolycarboxylic acid. A powerful, readily chelant. Complexing agent, exhibiting superior biological degradation (environmentally friendly) compared to EDTA. Used in cosmetic formulations, as effective anti-oxidant and water hardness control, to reduce radical generation, as effective peroxide stabiliser, as preservative potentiator improving piocide efficacy and excellent transition metal chelator.
Catalog Number:
(77439-456)
Supplier:
Bioss
Description:
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress through activation of NF-kappa-B.
Supplier:
AMBEED, INC
Description:
5-(4-(2-(5-Ethylpyridin-2-yl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione, Purity: 97%, CAS Number: 146062-49-9, Appearance: White to off-white powder or crystals, Storage: Sealed in dry, Store in freezer, under -20 C, Size: 2mg
Catalog Number:
(76100-130)
Supplier:
Bioss
Description:
Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.
Supplier:
Enzo Life Sciences
Description:
HNMPA-(AM)3 is a cell-permeable analog of HNMPA. It inhibits insulin receptor tyrosine kinase activity (IC50=100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50=10 µM). It has no effect on PKA (at concs. up to 1 mM) or PKC (at concs. up to 420 µM). Inhibits both serine and tyrosine autophosphorylation by the human insulin receptor. Does not affect protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).
Supplier:
Thermo Scientific Chemicals
Description:
99.9% (REO).Powder,WARNING: Irritates skin, eye, lungs; affects blood clotting,10g,2g.
Catalog Number:
(10297-344)
Supplier:
Bioss
Description:
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
Supplier:
Shenandoah Biotechnology
Description:
Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several alternatively spliced isoforms, with VEGF-165 being the most abundant. The VEGF-165 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell proliferation and angiogenesis.
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 048291-1G , MDL Number: MFCD00150741
Supplier:
Liveo
Description:
High vacuum grease is ideal for sealing and lubricating vacuum and pressure systems
Catalog Number:
(10244-962)
Supplier:
Bioss
Description:
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.
Supplier:
Thermo Scientific Chemicals
Description:
MDL: MFCD00149190
Fieser: 13,145 15,295
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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