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Catalog Number:
(77981-113)
Supplier:
LGC STANDARDS
Description:
Dasatinib monohydrate, TRC, LGC Standards
Catalog Number:
(EM8.22188.0500)
Catalog Number:
(10668-566)
Supplier:
Bioss
Description:
X-linked recessive myotubular myopathy is a congenital muscular disease characterized by severe hypotonia and generalized muscle weakness that, in most cases, leads to early postnatal death. The gene responsible for myotubular myopathy MTM1 encodes a dual specificity phosphatase, named myotubularin, which is highly conserved through evolution. The gene for MTM1 is localized to a 300 kb critical region on human Xq128 between IDS and GRBRA3. Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-Tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on phosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI3-kinase) pathway and membrane trafficking. Wild-type myotubularin can directly dephosphorylate PI3P and PI4P in vitro. Thus, it decreases PI3P levels by down-regulating PI3K activity and by facilitating the degradation of PI3P.
Catalog Number:
(10668-558)
Supplier:
Bioss
Description:
X-linked recessive myotubular myopathy is a congenital muscular disease characterized by severe hypotonia and generalized muscle weakness that, in most cases, leads to early postnatal death. The gene responsible for myotubular myopathy MTM1 encodes a dual specificity phosphatase, named myotubularin, which is highly conserved through evolution. The gene for MTM1 is localized to a 300 kb critical region on human Xq128 between IDS and GRBRA3. Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-Tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on phosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI3-kinase) pathway and membrane trafficking. Wild-type myotubularin can directly dephosphorylate PI3P and PI4P in vitro. Thus, it decreases PI3P levels by down-regulating PI3K activity and by facilitating the degradation of PI3P.
Supplier:
AMBEED, INC
Description:
Sodium (R)-2-((R)-1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, Purity: 99%, CAS Number: 6381-77-7, Appearance: Form: Crystal - Powder / Colour: White - Slightly pale yellow, Storage: Sealed in dry, Room Temperature, Size: 500G
Catalog Number:
(10301-088)
Supplier:
Bioss
Description:
RAPGEF6 is a guanine nucleotide exchange factor (GEF) that is expressed in a variety of tissues. Localizing to the cytoplasm and translocated to the plasma membrane upon ligand binding, RAPGEF6 contains an N-terminal Ras-GEF domain, a cyclic nucleotide monophosphate-binding domain, a PDZ (PSD-95/DlgA/ZO-1) domain, a Ras-associating (RA) domain and a Ras exchanger motif. RAPGEF6 is closely related to RAPGEF2 and both proteins exhibit GEF activity specific towards Rap 1 and Rap 2. In addition, RAPGEF6 is capable of binding to M-Ras via its RA domain. Due to alternative splicing events, two additional isoforms exist for RAPGEF6, namely PDZ-GEF2A and PDZ-GEF2B.
Supplier:
LGC STANDARDS
Description:
(RS)-Pantoic Acid Sodium Salt Monohydrate, TRC, LGC Standards
Catalog Number:
(10301-552)
Supplier:
Bioss
Description:
ITPase (inosine triphosphate pyrophosphatase) is also known as putative oncogene protein hlc14-06-p or ITPA (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)) and is a 194 amino acid protein. ITPase is abundantly expressed in heart, liver, sex glands, thyroid and adrenal gland, and is localized to the cytoplasm in the cell. ITPase catalyzes the pyrophosphohydrolysis of both ITP (inosine triphosphate) and dITP (deoxyinosine triphosphate) to IMP (inosine monophosphate) and diphosphate. IMP can be used as a substrate for purine nucleotide pathways. IMP can be phosphorylated to ITP, and ITPase can regulate the concentration of ITP in the cell by converting ITP back to IMP. Defects in ITPase result in ITPase deficiency which is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.
Catalog Number:
(76803-034)
Supplier:
AMBEED, INC
Description:
2,5-Dichloro-4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonic acid, Purity: 90+%, CAS Number: 84-57-1, Appearance: White to Orange to Green powder to crystal, Storage: Sealed in dry, Room Temperature, Size: 5G
Catalog Number:
(77993-519)
Supplier:
LGC STANDARDS
Description:
Sulfachloropyrazine Sodium Monohydrate, TRC, LGC Standards
Catalog Number:
(77078-192)
Supplier:
ANTIBODIES.COM LLC
Description:
Rabbit polyclonal antibody to ADORA2A for WB, IHC and ELISA with samples derived from Human.
Catalog Number:
(77678-751)
Supplier:
LGC STANDARDS
Description:
Sulfaclozine sodium monohydrate, Dr. Ehrenstorfer, LGC Standards
Catalog Number:
(77985-294)
Supplier:
LGC STANDARDS
Description:
D-Galacturonic Acid Monohydrate, TRC, LGC Standards
Catalog Number:
(77986-199)
Supplier:
LGC STANDARDS
Description:
Hydroxycitric Acid Tripotassium Salt Monohydrate, TRC, LGC Standards
Catalog Number:
(77693-478)
Supplier:
LGC STANDARDS
Description:
Vitamin D3 25-hydroxy monohydrate, Dr. Ehrenstorfer, LGC Standards
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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