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Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
5-Bromothiazole 95%
Catalog Number:
(101835-292)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 033243-500MG , MDL Number: MFCD01460736
Supplier:
Adipogen
Description:
Kinases, such as LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2), have been identified as participating in signal pathways affecting actin dynamics by deactivating cofilin. Over expression of LMK1 has been found in invasive breast and prostate cancer cell lines and suppression of LIMK 2 expression has been found to limit migration of human fibrosarcoma cells. Thus, the inhibition of LIMK1 and/or LIMK2 enzymes have been suggested as targets for treating cancer, including reduction or prevention of metastasis. BMS-5 is a potent inhibitor of the LIM kinase. It has IC(50) values of 7nM and 8nM for LIMK1 and LIMK2 respectively. LIMK1/2 activity was measured via TCA precipitation assay using a biotinylated ADF (actin depolymization factor) as the protein substrate and the kinase domains of LIMK1 and LIMK2 as the enzyme sources in the presence of 1µM ATP.
Catalog Number:
(101836-476)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 033845-500MG , MDL Number: MFCD11506551
Supplier:
AMBEED, INC
Description:
2-Bromo-4-methylthiazole 97%
Catalog Number:
(101934-252)
Supplier:
Matrix Scientific
Description:
MF=C19H27Cln2O3S MW=398.96 ,250Mg
Supplier:
TCI America
Description:
4-Bromothiazole, Purity: 98% (GC), Cas no. 34259-99-9, Molecular formula: C3H2BrNS, Form: Clear, Colour: Colorless - Pale yellow, Size: 1G
Supplier:
AMBEED, INC
Description:
2-Chlorothiazole 98%
Catalog Number:
(101798-016)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 010171-500MG , MDL Number: MFCD02224835
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 058731-5G , MDL Number: MFCD00829075
Supplier:
Promega Corporation
Description:
Firefly Luciferase Substrate for Use in Animal Imaging Studies.
Supplier:
ALADDIN SCIENTIFIC
Description:
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.Product Introduction:A cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration. Biochemical mechanism:Cell permeable: yesProduct competes with ATP.Primary TargethJNK 1, hJNK 2, hJNK 3Reversible: yesTarget IC50: 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively
Supplier:
AMBEED, INC
Description:
Ethyl 2-bromothiazole-4-carboxylate, Purity: 97%, CAS Number: 100367-77-9, Appearance: Form: Crystal - Powder, Storage: Keep in dark place, Inert atmosphere, Room temperature, Size: 10G
Supplier:
AMBEED, INC
Description:
2-(4-Fluorophenyl)-4-methylthiazole-5-carboxylic acid, Purity: 95%, CAS Number: 144060-99-1, Appearance: White to off-white solid, Storage: Sealed in dry, 2-8 C, Size: 1g
Supplier:
AMBEED, INC
Description:
2-Aminothiazole-5-carboxylic acid, Purity: 95%, CAS Number: 40283-46-3, Appearance: Solid, Storage: Keep in dark place, Inert atmosphere, 2-8 C, Size: 1g
Supplier:
Adipogen
Description:
CYC116 is an orally active small molecule multi-kinase inhibitor with anti-neoplastic activity. CYC116 inhibits Aurora kinases A/B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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