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(±)-Epoxystyrene
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(±)-Epoxystyrene
Catalog Number:
(89151-486)
Supplier:
Enzo Life Sciences
Catalog Number:
(102572-328)
Catalog Number:
(103008-636)
Supplier:
Anaspec Inc
Description:
This peptide is histone H4 amino acid residues 1 to 21. It is monomethylated at Arg3, with an acetylated N-terminus and C-terminal GG linker, followed by a biotinylated Lys. Methylation of histone H4 at Arg3 is an important step in transcriptional activation and allows for subsequent acetylation of H4 tails by p300. Provided at >90% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.'
Sequence:Ac-SG-R(Me1)-GKGGKGLGKGGAKRHRKV-GGK(Biotin) MW:2616.1 Da % peak area by HPLC:95 Storage condition:-20° C
Supplier:
BeanTown Chemical
Description:
CAS: 13194-68-8; EC No: 236-154-2; MDL No: MFCD00025299
UN No: UN2811; Haz Class: 6.1; Packing Group: III
Powder; Molecular Formula: C7H8IN ; MW: 233.05
Melting Point: 86-89°
Light Sensitive
Catalog Number:
(AA42773-AE)
Supplier:
Thermo Scientific Chemicals
Description:
sodium salt, 0.1% w/v Aqueous Solution,UN1170,Liquid,DANGER: FLAMMABLE, causes CNS effects, irritates skin & eyes,100ml.FLAMMABLE LIQUID,
Supplier:
Bachem Americas
Description:
Sequence: Boc-β-Ala-Trp-Met-Asp-Phe-NH₂
Synonym(s): AY 6608#ICI 50123#NSC 367746#Boc-(β-Ala¹³)-Gastrin (13-17)#Boc-β-Ala-CCK-4
Catalog Number:
(77438-234)
Supplier:
Bioss
Description:
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
Catalog Number:
(89358-802)
Supplier:
Genetex
Description:
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. [provided by RefSeq]
Catalog Number:
(10289-300)
Supplier:
Bioss
Description:
Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines, thereby repressing expression of the target gene. Dnmt3L (DNA (cytosine-5)-methyltransferase 3-like) is a 387 amino acid protein that contains one ADD-type zinc finger and is a member of the Dnmt family. Localized to the nucleus and expressed at lows levels in thymus, testis and ovary, Dnmt3L does not exhibit DNA methyltransferase activity, but is able to stimulate de novo methylation by Dnmt3 and is thought to play a key role in the establishment of genomic imprints. Additionally, Dnmt3L interacts with histone deacetylase 1 (HDAC1) and, through this interaction, mediates transcriptional repression. Multiple isoforms of Dnmt3L exist due to alternative splicing events.
Catalog Number:
(10289-284)
Supplier:
Bioss
Description:
Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines, thereby repressing expression of the target gene. Dnmt3L (DNA (cytosine-5)-methyltransferase 3-like) is a 387 amino acid protein that contains one ADD-type zinc finger and is a member of the Dnmt family. Localized to the nucleus and expressed at lows levels in thymus, testis and ovary, Dnmt3L does not exhibit DNA methyltransferase activity, but is able to stimulate de novo methylation by Dnmt3 and is thought to play a key role in the establishment of genomic imprints. Additionally, Dnmt3L interacts with histone deacetylase 1 (HDAC1) and, through this interaction, mediates transcriptional repression. Multiple isoforms of Dnmt3L exist due to alternative splicing events.
Catalog Number:
(103008-354)
Supplier:
Anaspec Inc
Description:
This peptide is Histone H3 amino acid residues 1 to 21. It is trimethylated at lysine 9 with a C-terminal GG linker, followed by a biotinylated lysine. The methylation of histone H3 at lysine is an important epigenetic mark of transcriptional silencing a
Sequence:ARTKQTAR-K(Me3)-STGGKAPRKQLA-GGK(Biotin)-NH2 MW:2764.2 Da % peak area by HPLC:95 Storage condition:-20° C
Catalog Number:
(76009-304)
Supplier:
Prosci
Description:
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. DNMT3A is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
Supplier:
Adipogen
Description:
ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation. ABT-737 exhibits single-agent-mechanism-based killing of cells from lymphoma and small-cell lung carcinoma lines, as well as primary patient-derived cells, and in animal models, ABT-737 improves survival, causes regression of established tumors, and produces cures in a high percentage of the mice. ABT-737 binds to Bcl-2, Bcl-xL and Bcl-w with very high affinities (Ki <lt/>1 nM) and also shows a very high specificity over Mcl-1 and A1.
Catalog Number:
(76011-686)
Supplier:
Prosci
Description:
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
Catalog Number:
(80053-496)
Supplier:
MilliporeSigma
Description:
Olomoucine is a purine derivative that acts as a potent and selective inhibitor of p34cdc2/Cyclin B (IC50=7µM) and related kinases, including p33cdk2/Cyclin A (IC50=7µM), p33cdk2/Cyclin E (IC50=7µM), p33cdk5/p35 (IC50=3µM), and p44 MAP kinase (IC50=25µM)
Catalog Number:
(76107-846)
Supplier:
Bioss
Description:
Leucine-rich repeats (LRRs) are 20-29 amino acid motifs that mediate protein-protein interactions. The primary function of these motifs is to provide a versatile structural framework for the formation of these protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. Several human diseases are associated with mutation in the genes encoding LRR-containing proteins. The leucine-rich repeat-containing protein 3B (LRRC3B), also designated LRP15, is a 259 amino acid protein that contains 3 LRR repeats. The gene encoding LRRC3B is a tumor suppressor gene that is regulated by DNA methylation. Decreased expression of LRRC3B has been shown in colorectal cancer and gastric cancer, making LRRC3B a candidate marker for those cancers.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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