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3-(Hydroxymethyl)-1-methyl-1H-indazole
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3-(Hydroxymethyl)-1-methyl-1H-indazole
Catalog Number:
(10300-352)
Supplier:
Bioss
Description:
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide (NO). The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide. It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme-containing heterodimer, consisting of one alpha subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide (CO), which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver.
Catalog Number:
(10300-356)
Supplier:
Bioss
Description:
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide (NO). The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide. It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme-containing heterodimer, consisting of one alpha subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide (CO), which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver.
Catalog Number:
(10300-350)
Supplier:
Bioss
Description:
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide (NO). The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide. It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme-containing heterodimer, consisting of one alpha subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide (CO), which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver.
Catalog Number:
(102835-408)
Supplier:
Matrix Scientific
Description:
4-(Trifluoromethyl)nicotinaldehyde 95
Catalog Number:
(AAAL19554-03)
Supplier:
BeanTown Chemical
Description:
CAS: 542-69-8; EC No: 208-824-4; MDL No: MFCD00001098; RTECS: EK4400000
UN No: UN1993; Haz Class: 3; Packing Group: III
Liquid; Linear Formula: CH3(CH2)3I; Molecular Formula: C4H9I; MW: 184.02
Melting Point: -103°; Boiling Point: 130-131°; Flash point: 33°C (91°F)
Density (g/mL): 1.617; Refractive Index: 1.498
Light Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 107-08-4; EC No: 203-460-2; MDL No: MFCD00001095; RTECS: TZ4100000
UN No: UN2392; Haz Class: 3; Packing Group: III
Liquid; Linear Formula: CH3CH2CH2I; Molecular Formula: C3H7I; MW: 169.99
Melting Point: -101°; Boiling Point: 101-102°; Flash point: 44°C (111°F)
Density (g/mL): 1.743; Refractive Index: 1.504
Light Sensitive
Supplier:
APOLLO SCIENTIFIC
Description:
3-(Trifluoromethyl)benzylamine 97%
Supplier:
Matrix Scientific
Description:
MF=C7H6Cli MW=252.48 Cas=23399-70-4 MDL=MFCD00060665 100G
Supplier:
Matrix Scientific
Description:
MF=C4F9Io3S MW=426.00 Cas=66137-74-4 MDL=MFCD00798139 ,5G
Supplier:
Matrix Scientific
Description:
MF=C6H3Brfi MW=300.90 Cas=136434-77-0 MDL=MFCD00042577 100G
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 009196-5G , MDL Number: MFCD00156050
Supplier:
Thermo Scientific Chemicals
Description:
2-[4-(Trifluoromethyl)phenyl]ethylamine, 98%
Supplier:
APOLLO SCIENTIFIC
Description:
(S)-2-(Trifluoromethyl)pyrrolidine 97%
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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